INT320691

Context Info Confidence 0.06 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 2.15 Pain Relevance 0.34

extracellular space (C5) extracellular region (C5)

C5 (Rattus norvegicus) Il1 (Mus musculus)

Pain Link Frequency Relevance Heat Inflammatory mediators 2 100.00 cytokine 42 98.28 Inflammation 34 97.88 Inflammatory response 22 85.96 cva 35 79.76 vagus nerve 9 5.00 agonist 5 5.00 anesthesia 4 5.00 ischemia 4 5.00 Central nervous system 2 5.00

Disease Link Frequency Relevance Heat INFLAMMATION 56 100.00 Systemic Inflammatory Response Syndrome 10 99.12 Multiple Organ Failure 8 92.76 Sepsis 64 88.44 Cv Unclassified Under Development 8 87.80 Coagulation Disorder 2 84.16 Pancreatitis 1 83.08 Pneumonia 1 82.52 Disease 1 81.48 Hemorrhage 36 79.76

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

In addition to over production of TNF, IL-1, IL-2, IL-6, and IL-12, other inflammatory mediators such as C5a involve the complement cascade.

C5a Regulation (involve) of Gene_expression (production) of IL-1 associated with inflammatory mediators

1) Confidence 0.06 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2902015 Disease Relevance 2.15 Pain Relevance 0.34

General Comments

This test has worked.