INT320730

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Context Info
Confidence 0.60
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 1.84
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (NBN) nucleolus (NBN) chromosome (NBN)
nucleus (NBN) intracellular (NBN) cell cycle (NBN)
NBN (Homo sapiens)
Pain Link Frequency Relevance Heat
palliative 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Melanoma 182 99.56 Very High Very High Very High
Cancer 112 95.72 Very High Very High Very High
Disease 8 81.00 Quite High
Apoptosis 8 62.56 Quite High
Metastasis 60 58.80 Quite High
Skin Cancer 124 50.00 Quite Low
Congenital Anomalies 8 26.44 Quite Low
Chromosome Aberrations 20 25.68 Quite Low
Monosomy 40 14.16 Low Low
Aneuploidy 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The NBS1-gene is found to be overexpressed in 50% of UM [62].
Positive_regulation (overexpressed) of Gene_expression (overexpressed) of NBS1-gene associated with melanoma
1) Confidence 0.60 Published 2010 Journal Dermatology Research and Practice Section Body Doc Link PMC2902045 Disease Relevance 0.93 Pain Relevance 0
It is theorized that overexpressed NBS1 could allow UM progression by promoting the repair of DNA damage which occurs more frequently in advanced tumors with increased genetic instability.
Positive_regulation (overexpressed) of Gene_expression (overexpressed) of NBS1 associated with cancer and melanoma
2) Confidence 0.40 Published 2010 Journal Dermatology Research and Practice Section Body Doc Link PMC2902045 Disease Relevance 0.91 Pain Relevance 0

General Comments

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