INT320739

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Context Info
Confidence 0.63
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 6
Disease Relevance 8.03
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell adhesion (Dsg2) plasma membrane (Dsg2)
Anatomy Link Frequency
epidermis 4
Dsg2 (Mus musculus)
Pain Link Frequency Relevance Heat
corticosteroid 6 5.00 Very Low Very Low Very Low
cINOD 6 5.00 Very Low Very Low Very Low
imagery 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 258 100.00 Very High Very High Very High
Bullous Skin Disease 360 99.46 Very High Very High Very High
Blister 216 99.24 Very High Very High Very High
Adhesions 78 98.76 Very High Very High Very High
Disease 48 94.36 High High
Congenital Anomalies 6 89.68 High High
Hyperplasia 6 81.92 Quite High
Acantholysis 12 38.16 Quite Low
Skin Infection 30 34.36 Quite Low
Streptococcus Infection 6 24.56 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We observed that overexpression of Dsg2 provided enhanced protection against blister formation in response to ETA (Figure 2(c)).
Positive_regulation (overexpression) of Gene_expression (overexpression) of Dsg2 associated with blister
1) Confidence 0.63 Published 2010 Journal Dermatology Research and Practice Section Body Doc Link PMC2902105 Disease Relevance 0.96 Pain Relevance 0
Collectively, our results demonstrate that ectopic expression of Dsg2 could partially compensate for the loss of Dsg1-mediated adhesion in response to ETA digestion.

2.3.

Positive_regulation (compensate) of Gene_expression (expression) of Dsg2 associated with adhesions
2) Confidence 0.46 Published 2010 Journal Dermatology Research and Practice Section Body Doc Link PMC2902105 Disease Relevance 1.22 Pain Relevance 0
Also, suprabasal expression of Dsg2 in Tg mice offers greater protection against PF Ig, as compared to ETA (Figure 4).
Positive_regulation (suprabasal) of Gene_expression (expression) of Dsg2 associated with targeted disruption and bullous skin disease
3) Confidence 0.46 Published 2010 Journal Dermatology Research and Practice Section Body Doc Link PMC2902105 Disease Relevance 1.34 Pain Relevance 0
Thus, our results demonstrate that, at the Western blot level, PF Ig depletes Dsg1 and that superficial expression of Dsg2 in Tg mice did not appear to modulate the level of Dsg1 in response to PF Ig.
Positive_regulation (superficial) of Gene_expression (expression) of Dsg2 associated with targeted disruption and bullous skin disease
4) Confidence 0.46 Published 2010 Journal Dermatology Research and Practice Section Body Doc Link PMC2902105 Disease Relevance 1.71 Pain Relevance 0
In summary, we generated transgenic mice expressing Dsg2 in the superficial epidermis of newborn mice.

2.2.

Positive_regulation (generated) of Gene_expression (generated) of Dsg2 in epidermis associated with targeted disruption
5) Confidence 0.40 Published 2010 Journal Dermatology Research and Practice Section Body Doc Link PMC2902105 Disease Relevance 1.14 Pain Relevance 0
As previously described in detail, we generated Tg mice expressing Dsg2 in the superficial epidermis, under the control of the involucrin promoter [14].
Positive_regulation (generated) of Gene_expression (expressing) of Dsg2 in epidermis associated with targeted disruption
6) Confidence 0.37 Published 2010 Journal Dermatology Research and Practice Section Body Doc Link PMC2902105 Disease Relevance 1.66 Pain Relevance 0

General Comments

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