INT320743

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Context Info
Confidence 0.39
First Reported 2010
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 3.95
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell adhesion (Dsg2) plasma membrane (Dsg2)
Anatomy Link Frequency
epidermis 4
Dsg2 (Mus musculus)
Pain Link Frequency Relevance Heat
corticosteroid 3 5.00 Very Low Very Low Very Low
cINOD 3 5.00 Very Low Very Low Very Low
imagery 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Bullous Skin Disease 180 99.76 Very High Very High Very High
Blister 108 98.64 Very High Very High Very High
Targeted Disruption 129 95.36 Very High Very High Very High
Disease 24 74.60 Quite High
Acantholysis 6 73.96 Quite High
Adhesions 39 63.36 Quite High
Hyperplasia 3 8.96 Low Low
Congenital Anomalies 3 5.16 Low Low
Skin Infection 15 5.00 Very Low Very Low Very Low
Streptococcus Infection 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Next, we wanted to evaluate whether or not superficial expression of Dsg2 had an effect on Dsg1 fate and localization in response to PF Ig.
Spec (whether) Negative_regulation (superficial) of Gene_expression (expression) of Dsg2 associated with bullous skin disease
1) Confidence 0.39 Published 2010 Journal Dermatology Research and Practice Section Body Doc Link PMC2902105 Disease Relevance 1.46 Pain Relevance 0
In this paper, we demonstrate that ectopic expression of Dsg2 in the superficial epidermis could limit both PF Ig- and ETA-induced skin blister formation, suggesting that steric hindrance plays a role in the mechanism of pemphigus.
Negative_regulation (limit) of in skin Gene_expression (expression) of Dsg2 in epidermis associated with blister and bullous skin disease
2) Confidence 0.39 Published 2010 Journal Dermatology Research and Practice Section Body Doc Link PMC2902105 Disease Relevance 1.44 Pain Relevance 0
These results suggest that coexpression of Dsg2 with Dsg1 in the superficial epidermis may protect from the loss of Dsg1 by ETA although we cannot rule out the possibility that ectopic expression of Dsg2 may also impair the ETA-digestion of Dsg1 molecules.
Negative_regulation (impair) of Gene_expression (expression) of Dsg2 in epidermis
3) Confidence 0.39 Published 2010 Journal Dermatology Research and Practice Section Body Doc Link PMC2902105 Disease Relevance 1.05 Pain Relevance 0

General Comments

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