INT320743

Context Info Confidence 0.39 First Reported 2010 Last Reported 2010 Negated 0 Speculated 1 Reported most in Body Documents 1 Total Number 3 Disease Relevance 3.95 Pain Relevance 0

cell adhesion (Dsg2) plasma membrane (Dsg2)

Anatomy Link Frequency epidermis 4 Dsg2 (Mus musculus)

Pain Link Frequency Relevance Heat corticosteroid 3 5.00 cINOD 3 5.00 imagery 3 5.00

Disease Link Frequency Relevance Heat Bullous Skin Disease 180 99.76 Blister 108 98.64 Targeted Disruption 129 95.36 Disease 24 74.60 Acantholysis 6 73.96 Adhesions 39 63.36 Hyperplasia 3 8.96 Congenital Anomalies 3 5.16 Skin Infection 15 5.00 Streptococcus Infection 3 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Next, we wanted to evaluate whether or not superficial expression of Dsg2 had an effect on Dsg1 fate and localization in response to PF Ig.

Spec (whether) Negative_regulation (superficial) of Gene_expression (expression) of Dsg2 associated with bullous skin disease

1) Confidence 0.39 Published 2010 Journal Dermatology Research and Practice Section Body Doc Link PMC2902105 Disease Relevance 1.46 Pain Relevance 0

In this paper, we demonstrate that ectopic expression of Dsg2 in the superficial epidermis could limit both PF Ig- and ETA-induced skin blister formation, suggesting that steric hindrance plays a role in the mechanism of pemphigus.

Negative_regulation (limit) of in skin Gene_expression (expression) of Dsg2 in epidermis associated with blister and bullous skin disease

2) Confidence 0.39 Published 2010 Journal Dermatology Research and Practice Section Body Doc Link PMC2902105 Disease Relevance 1.44 Pain Relevance 0

These results suggest that coexpression of Dsg2 with Dsg1 in the superficial epidermis may protect from the loss of Dsg1 by ETA although we cannot rule out the possibility that ectopic expression of Dsg2 may also impair the ETA-digestion of Dsg1 molecules.

Negative_regulation (impair) of Gene_expression (expression) of Dsg2 in epidermis

3) Confidence 0.39 Published 2010 Journal Dermatology Research and Practice Section Body Doc Link PMC2902105 Disease Relevance 1.05 Pain Relevance 0

General Comments

This test has worked.