INT320743
From wiki-pain
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Sentences Mentioned In
Key: | Protein | Mutation | Event | Anatomy | Negation | Speculation | Pain term | Disease term |
Next, we wanted to evaluate whether or not superficial expression of Dsg2 had an effect on Dsg1 fate and localization in response to PF Ig. | |||||||||||||||
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In this paper, we demonstrate that ectopic expression of Dsg2 in the superficial epidermis could limit both PF Ig- and ETA-induced skin blister formation, suggesting that steric hindrance plays a role in the mechanism of pemphigus. | |||||||||||||||
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These results suggest that coexpression of Dsg2 with Dsg1 in the superficial epidermis may protect from the loss of Dsg1 by ETA although we cannot rule out the possibility that ectopic expression of Dsg2 may also impair the ETA-digestion of Dsg1 molecules. | |||||||||||||||
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General Comments
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