INT320746

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Context Info
Confidence 0.48
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 5
Disease Relevance 6.43
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell adhesion (Dsg1a) plasma membrane (Dsg1a)
Anatomy Link Frequency
skin 1
Dsg1a (Mus musculus)
Pain Link Frequency Relevance Heat
corticosteroid 5 5.00 Very Low Very Low Very Low
cINOD 5 5.00 Very Low Very Low Very Low
imagery 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Adhesions 65 100.00 Very High Very High Very High
Skin Diseases 5 98.68 Very High Very High Very High
Bullous Skin Disease 300 98.56 Very High Very High Very High
Blister 180 98.44 Very High Very High Very High
Targeted Disruption 215 98.12 Very High Very High Very High
Disease 40 97.32 Very High Very High Very High
Acantholysis 10 96.68 Very High Very High Very High
Monilethrix 5 95.40 Very High Very High Very High
Streptococcus Infection 5 57.92 Quite High
Skin Infection 25 55.12 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Indeed, in the case of PF, anti-Dsg1 antibodies can induce blister formation by triggering intracellular signaling pathways, without disrupting Dsg1-Dsg1 interactions [23].
Dsg1-Dsg1 Binding (interactions) of associated with blister and bullous skin disease
1) Confidence 0.48 Published 2010 Journal Dermatology Research and Practice Section Body Doc Link PMC2902105 Disease Relevance 1.36 Pain Relevance 0
To further confirm these results, we immunostained ETA-treated WT and Tg skin with antibody 27B2, which was raised against the intracellular domain of human Dsg1 and recognizes all three mouse Dsg1s.
Dsg1s Binding (recognizes) of in skin associated with targeted disruption
2) Confidence 0.48 Published 2010 Journal Dermatology Research and Practice Section Body Doc Link PMC2902105 Disease Relevance 0.99 Pain Relevance 0
This disorder is generally characterized by the production of pathogenic antibodies targeting different components of cell-cell adhesion, in particular, Dsg1 and Dsg3.
Dsg1 Binding (characterized) of associated with adhesions
3) Confidence 0.37 Published 2010 Journal Dermatology Research and Practice Section Body Doc Link PMC2902105 Disease Relevance 1.36 Pain Relevance 0
In the case of PF Ig, increased adhesion may compensate for possible steric hindrance of desmoglein trans-interaction induced by antibody-antigen binding [6, 18, 19].
desmoglein Binding (interaction) of associated with bullous skin disease and adhesions
4) Confidence 0.36 Published 2010 Journal Dermatology Research and Practice Section Body Doc Link PMC2902105 Disease Relevance 1.33 Pain Relevance 0
Steric hindrance of desmoglein trans-interaction induced by antibody-antigen binding was initially proposed based on evidence that one desmoglein could compensate for the loss of another [6, 18, 19].
desmoglein Binding (interaction) of
5) Confidence 0.36 Published 2010 Journal Dermatology Research and Practice Section Body Doc Link PMC2902105 Disease Relevance 1.39 Pain Relevance 0

General Comments

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