INT320750

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Context Info
Confidence 0.45
First Reported 2010
Last Reported 2010
Negated 1
Speculated 1
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 3.44
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell adhesion (Dsg1a) plasma membrane (Dsg1a)
Anatomy Link Frequency
skin 2
Dsg1a (Mus musculus)
Pain Link Frequency Relevance Heat
corticosteroid 2 5.00 Very Low Very Low Very Low
cINOD 2 5.00 Very Low Very Low Very Low
imagery 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 86 99.52 Very High Very High Very High
Bullous Skin Disease 120 99.36 Very High Very High Very High
Blister 72 90.72 High High
Disease 16 49.84 Quite Low
Adhesions 26 37.68 Quite Low
Skin Infection 10 5.00 Very Low Very Low Very Low
Acantholysis 4 5.00 Very Low Very Low Very Low
Hyperplasia 2 5.00 Very Low Very Low Very Low
Streptococcus Infection 2 5.00 Very Low Very Low Very Low
Congenital Anomalies 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Thus, our results demonstrate that, at the Western blot level, PF Ig depletes Dsg1 and that superficial expression of Dsg2 in Tg mice did not appear to modulate the level of Dsg1 in response to PF Ig.
Spec (appear) Regulation (modulate) of Gene_expression (level) of Dsg1 associated with targeted disruption and bullous skin disease
1) Confidence 0.45 Published 2010 Journal Dermatology Research and Practice Section Body Doc Link PMC2902105 Disease Relevance 1.64 Pain Relevance 0
Western blotting showed that (1) up-regulation of Dsg2 did not alter the expression level of Dsg1 in newborn mouse skin, and (2) incubation with PF Ig reduced the level of Dsg1 (Figure 4(d)).
Neg (not) Regulation (alter) of Gene_expression (expression) of Dsg1 in skin associated with bullous skin disease
2) Confidence 0.27 Published 2010 Journal Dermatology Research and Practice Section Body Doc Link PMC2902105 Disease Relevance 1.80 Pain Relevance 0

General Comments

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