INT320750

Context Info Confidence 0.45 First Reported 2010 Last Reported 2010 Negated 1 Speculated 1 Reported most in Body Documents 1 Total Number 2 Disease Relevance 3.44 Pain Relevance 0

cell adhesion (Dsg1a) plasma membrane (Dsg1a)

Anatomy Link Frequency skin 2 Dsg1a (Mus musculus)

Pain Link Frequency Relevance Heat corticosteroid 2 5.00 cINOD 2 5.00 imagery 2 5.00

Disease Link Frequency Relevance Heat Targeted Disruption 86 99.52 Bullous Skin Disease 120 99.36 Blister 72 90.72 Disease 16 49.84 Adhesions 26 37.68 Skin Infection 10 5.00 Acantholysis 4 5.00 Hyperplasia 2 5.00 Streptococcus Infection 2 5.00 Congenital Anomalies 2 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Thus, our results demonstrate that, at the Western blot level, PF Ig depletes Dsg1 and that superficial expression of Dsg2 in Tg mice did not appear to modulate the level of Dsg1 in response to PF Ig.

Spec (appear) Regulation (modulate) of Gene_expression (level) of Dsg1 associated with targeted disruption and bullous skin disease

1) Confidence 0.45 Published 2010 Journal Dermatology Research and Practice Section Body Doc Link PMC2902105 Disease Relevance 1.64 Pain Relevance 0

Western blotting showed that (1) up-regulation of Dsg2 did not alter the expression level of Dsg1 in newborn mouse skin, and (2) incubation with PF Ig reduced the level of Dsg1 (Figure 4(d)).

Neg (not) Regulation (alter) of Gene_expression (expression) of Dsg1 in skin associated with bullous skin disease

2) Confidence 0.27 Published 2010 Journal Dermatology Research and Practice Section Body Doc Link PMC2902105 Disease Relevance 1.80 Pain Relevance 0

General Comments

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