INT320758

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Context Info
Confidence 0.80
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 4
Disease Relevance 4.07
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell adhesion (Dsg1a) plasma membrane (Dsg1a)
Anatomy Link Frequency
cleavage 1
Dsg1a (Mus musculus)
Pain Link Frequency Relevance Heat
corticosteroid 4 5.00 Very Low Very Low Very Low
cINOD 4 5.00 Very Low Very Low Very Low
imagery 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Bullous Skin Disease 240 99.36 Very High Very High Very High
Blister 144 98.68 Very High Very High Very High
Targeted Disruption 172 93.44 High High
Disease 32 33.00 Quite Low
Adhesions 52 20.84 Low Low
Acantholysis 8 18.36 Low Low
Skin Infection 20 5.00 Very Low Very Low Very Low
Hyperplasia 4 5.00 Very Low Very Low Very Low
Streptococcus Infection 4 5.00 Very Low Very Low Very Low
Congenital Anomalies 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Next, we wanted to evaluate whether or not superficial expression of Dsg2 had an effect on Dsg1 fate and localization in response to PF Ig.
Localization (localization) of Dsg1 associated with bullous skin disease
1) Confidence 0.80 Published 2010 Journal Dermatology Research and Practice Section Body Doc Link PMC2902105 Disease Relevance 1.45 Pain Relevance 0
For instance, whereas PF antibodies disrupt and reduce cell-cell border staining of Dsg1 (Figure 5), ETA cleavage does not appear to alter the plasma membrane localization of Dsg1 despite inducing extensive skin blisters (Figure 3).
Localization (localization) of Dsg1 in cleavage associated with blister and bullous skin disease
2) Confidence 0.80 Published 2010 Journal Dermatology Research and Practice Section Body Doc Link PMC2902105 Disease Relevance 1.07 Pain Relevance 0
In WT animals, PF Ig treatment induced extensive redistribution of Dsg1-?
Localization (redistribution) of Dsg1 associated with bullous skin disease
3) Confidence 0.75 Published 2010 Journal Dermatology Research and Practice Section Body Doc Link PMC2902105 Disease Relevance 0.75 Pain Relevance 0
Next, we assessed the expression and localization of Dsg1 (?
Localization (localization) of Dsg1
4) Confidence 0.71 Published 2010 Journal Dermatology Research and Practice Section Body Doc Link PMC2902105 Disease Relevance 0.81 Pain Relevance 0

General Comments

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