INT320761

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 1.00
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 6
Disease Relevance 6.90
Pain Relevance 0.11

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell adhesion (Dsg1a) plasma membrane (Dsg1a)
Anatomy Link Frequency
skin 4
Dsg1a (Mus musculus)
Pain Link Frequency Relevance Heat
corticosteroid 6 77.44 Quite High
cINOD 6 72.64 Quite High
imagery 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Blister 216 99.92 Very High Very High Very High
Bullous Skin Disease 360 99.54 Very High Very High Very High
Targeted Disruption 258 98.60 Very High Very High Very High
Skin Infection 30 98.04 Very High Very High Very High
Streptococcus Infection 6 96.66 Very High Very High Very High
Disease 48 96.32 Very High Very High Very High
Adhesions 78 93.84 High High
Acantholysis 12 78.12 Quite High
INFLAMMATION 6 72.24 Quite High
Skin Diseases 6 65.44 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
What remains to be addressed in future studies is (1) whether ectopic expression of Dsg2 alters the sensitivity of Dsg1 to degradation by ETA or loss of function upon antibody binding, and (2) whether the loss of Dsg1 function in pemphigus is caused by altered signaling and/or steric hindrance.
Protein_catabolism (degradation) of Dsg1 associated with bullous skin disease
1) Confidence 1.00 Published 2010 Journal Dermatology Research and Practice Section Body Doc Link PMC2902105 Disease Relevance 0.77 Pain Relevance 0.11
Furthermore, toxins such as ETA can induce PF-like skin blisters by proteolysis of Dsg1 in the absence of antibody binding [16].
Protein_catabolism (proteolysis) of Dsg1 in skin associated with blister and bullous skin disease
2) Confidence 1.00 Published 2010 Journal Dermatology Research and Practice Section Body Doc Link PMC2902105 Disease Relevance 1.53 Pain Relevance 0
Western blotting showed that ETA cleaves Dsg1, resulting in a smaller fragment approximately 113?
Protein_catabolism (cleaves) of Dsg1
3) Confidence 0.66 Published 2010 Journal Dermatology Research and Practice Section Body Doc Link PMC2902105 Disease Relevance 0.64 Pain Relevance 0
To confirm that ETA cleaves mouse Dsg1 when injected into newborn WT and Tg mice, skin biopsies were taken after ETA treatment and the total cellular proteins were extracted in Laemmli buffer.
Protein_catabolism (cleaves) of Dsg1 in skin associated with targeted disruption
4) Confidence 0.66 Published 2010 Journal Dermatology Research and Practice Section Body Doc Link PMC2902105 Disease Relevance 0.83 Pain Relevance 0
It is well established that ETA cleaves Dsg1 and causes epidermal blisters in the upper layers of the epidermis, where Dsg1 is highly expressed [16].
Protein_catabolism (cleaves) of Dsg1 in epidermis associated with blister
5) Confidence 0.66 Published 2010 Journal Dermatology Research and Practice Section Body Doc Link PMC2902105 Disease Relevance 1.21 Pain Relevance 0
Interestingly, in the toxin-mediated disease bullous impetigo (and its generalized form staphylococcal scalded skin syndrome (SSSS)), the bacterium S. aureus produces exfoliative toxins (glutamic-specific serine proteases) that cleave Dsg1 between extracellular domains 3 and 4 [7].
Protein_catabolism (cleave) of Dsg1 in skin associated with streptococcus infection, skin infection and disease
6) Confidence 0.57 Published 2010 Journal Dermatology Research and Practice Section Body Doc Link PMC2902105 Disease Relevance 1.92 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox