INT320763

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Context Info
Confidence 0.41
First Reported 2010
Last Reported 2010
Negated 0
Speculated 2
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 4.84
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell adhesion (Dsg2) plasma membrane (Dsg2)
Anatomy Link Frequency
epidermis 2
Dsg2 (Mus musculus)
Pain Link Frequency Relevance Heat
corticosteroid 3 5.00 Very Low Very Low Very Low
cINOD 3 5.00 Very Low Very Low Very Low
imagery 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 129 100.00 Very High Very High Very High
Bullous Skin Disease 180 99.22 Very High Very High Very High
Disease 24 93.64 High High
Congenital Anomalies 3 92.56 High High
Blister 108 87.24 High High
Hyperplasia 3 84.80 Quite High
Adhesions 39 66.68 Quite High
Skin Infection 15 33.64 Quite Low
Streptococcus Infection 3 23.84 Low Low
Acantholysis 6 5.68 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Next, we wanted to evaluate whether or not superficial expression of Dsg2 had an effect on Dsg1 fate and localization in response to PF Ig.
Spec (whether) Regulation (effect) of Gene_expression (expression) of Dsg2 associated with bullous skin disease
1) Confidence 0.41 Published 2010 Journal Dermatology Research and Practice Section Body Doc Link PMC2902105 Disease Relevance 1.46 Pain Relevance 0
Thus, our results demonstrate that, at the Western blot level, PF Ig depletes Dsg1 and that superficial expression of Dsg2 in Tg mice did not appear to modulate the level of Dsg1 in response to PF Ig.
Spec (appear) Regulation (modulate) of Gene_expression (expression) of Dsg2 associated with targeted disruption and bullous skin disease
2) Confidence 0.41 Published 2010 Journal Dermatology Research and Practice Section Body Doc Link PMC2902105 Disease Relevance 1.72 Pain Relevance 0
As previously described in detail, we generated Tg mice expressing Dsg2 in the superficial epidermis, under the control of the involucrin promoter [14].
Regulation (under) of Gene_expression (expressing) of Dsg2 in epidermis associated with targeted disruption
3) Confidence 0.22 Published 2010 Journal Dermatology Research and Practice Section Body Doc Link PMC2902105 Disease Relevance 1.66 Pain Relevance 0

General Comments

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