INT320768

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Context Info
Confidence 0.08
First Reported 2010
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.77
Pain Relevance 0.11

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell adhesion (Spp1, Dsg1a) extracellular space (Spp1) extracellular region (Spp1)
plasma membrane (Dsg1a) cytoplasm (Spp1)
Spp1 (Mus musculus)
Dsg1a (Mus musculus)
Pain Link Frequency Relevance Heat
corticosteroid 1 78.00 Quite High
cINOD 1 73.20 Quite High
imagery 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Bullous Skin Disease 60 96.44 Very High Very High Very High
Adhesions 13 94.88 High High
Targeted Disruption 43 79.24 Quite High
INFLAMMATION 1 72.80 Quite High
Blister 36 50.00 Quite Low
Disease 8 12.96 Low Low
Skin Infection 5 5.00 Very Low Very Low Very Low
Acantholysis 2 5.00 Very Low Very Low Very Low
Hyperplasia 1 5.00 Very Low Very Low Very Low
Streptococcus Infection 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
What remains to be addressed in future studies is (1) whether ectopic expression of Dsg2 alters the sensitivity of Dsg1 to degradation by ETA or loss of function upon antibody binding, and (2) whether the loss of Dsg1 function in pemphigus is caused by altered signaling and/or steric hindrance.
ETA Spec (whether) Regulation (alters) of Protein_catabolism (degradation) of Dsg1 associated with bullous skin disease
1) Confidence 0.08 Published 2010 Journal Dermatology Research and Practice Section Body Doc Link PMC2902105 Disease Relevance 0.77 Pain Relevance 0.11

General Comments

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