INT320769

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Context Info
Confidence 0.05
First Reported 2010
Last Reported 2010
Negated 0
Speculated 2
Reported most in Body
Documents 1
Total Number 4
Disease Relevance 5.87
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Atp11c, Dsg1a) cell adhesion (Dsg1a) endoplasmic reticulum (Atp11c)
Anatomy Link Frequency
skin 1
Atp11c (Mus musculus)
Dsg1a (Mus musculus)
Pain Link Frequency Relevance Heat
corticosteroid 4 5.00 Very Low Very Low Very Low
cINOD 4 5.00 Very Low Very Low Very Low
imagery 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Bullous Skin Disease 240 100.00 Very High Very High Very High
Targeted Disruption 172 99.52 Very High Very High Very High
Blister 144 99.40 Very High Very High Very High
Disease 32 58.52 Quite High
Adhesions 52 46.36 Quite Low
Skin Infection 20 5.00 Very Low Very Low Very Low
Acantholysis 8 5.00 Very Low Very Low Very Low
Hyperplasia 4 5.00 Very Low Very Low Very Low
Streptococcus Infection 4 5.00 Very Low Very Low Very Low
Congenital Anomalies 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Intriguingly, PF Ig had a minor effect on Dsg1-?
Ig Regulation (effect) of Dsg1 associated with bullous skin disease
1) Confidence 0.05 Published 2010 Journal Dermatology Research and Practice Section Body Doc Link PMC2902105 Disease Relevance 0.77 Pain Relevance 0
Thus, our results demonstrate that, at the Western blot level, PF Ig depletes Dsg1 and that superficial expression of Dsg2 in Tg mice did not appear to modulate the level of Dsg1 in response to PF Ig.
Ig Spec (appear) Regulation (modulate) of Dsg1 associated with targeted disruption and bullous skin disease
2) Confidence 0.03 Published 2010 Journal Dermatology Research and Practice Section Body Doc Link PMC2902105 Disease Relevance 1.65 Pain Relevance 0
Next, we wanted to evaluate whether or not superficial expression of Dsg2 had an effect on Dsg1 fate and localization in response to PF Ig.
Ig Spec (whether) Regulation (effect) of Dsg1 associated with bullous skin disease
3) Confidence 0.03 Published 2010 Journal Dermatology Research and Practice Section Body Doc Link PMC2902105 Disease Relevance 1.46 Pain Relevance 0
To test the effects of PF Ig on epidermal Dsg1, skin biopsies were collected after PF Ig treatment, and the total cellular proteins were extracted in Laemmli buffer.
Ig Regulation (effects) of Dsg1 in skin associated with bullous skin disease
4) Confidence 0.03 Published 2010 Journal Dermatology Research and Practice Section Body Doc Link PMC2902105 Disease Relevance 1.98 Pain Relevance 0

General Comments

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