INT320769

Context Info Confidence 0.05 First Reported 2010 Last Reported 2010 Negated 0 Speculated 2 Reported most in Body Documents 1 Total Number 4 Disease Relevance 5.87 Pain Relevance 0

plasma membrane (Atp11c, Dsg1a) cell adhesion (Dsg1a) endoplasmic reticulum (Atp11c)

Anatomy Link Frequency skin 1 Atp11c (Mus musculus) Dsg1a (Mus musculus)

Pain Link Frequency Relevance Heat corticosteroid 4 5.00 cINOD 4 5.00 imagery 4 5.00

Disease Link Frequency Relevance Heat Bullous Skin Disease 240 100.00 Targeted Disruption 172 99.52 Blister 144 99.40 Disease 32 58.52 Adhesions 52 46.36 Skin Infection 20 5.00 Acantholysis 8 5.00 Hyperplasia 4 5.00 Streptococcus Infection 4 5.00 Congenital Anomalies 4 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Intriguingly, PF Ig had a minor effect on Dsg1-?

Ig Regulation (effect) of Dsg1 associated with bullous skin disease

1) Confidence 0.05 Published 2010 Journal Dermatology Research and Practice Section Body Doc Link PMC2902105 Disease Relevance 0.77 Pain Relevance 0

Thus, our results demonstrate that, at the Western blot level, PF Ig depletes Dsg1 and that superficial expression of Dsg2 in Tg mice did not appear to modulate the level of Dsg1 in response to PF Ig.

Ig Spec (appear) Regulation (modulate) of Dsg1 associated with targeted disruption and bullous skin disease

2) Confidence 0.03 Published 2010 Journal Dermatology Research and Practice Section Body Doc Link PMC2902105 Disease Relevance 1.65 Pain Relevance 0

Next, we wanted to evaluate whether or not superficial expression of Dsg2 had an effect on Dsg1 fate and localization in response to PF Ig.

Ig Spec (whether) Regulation (effect) of Dsg1 associated with bullous skin disease

3) Confidence 0.03 Published 2010 Journal Dermatology Research and Practice Section Body Doc Link PMC2902105 Disease Relevance 1.46 Pain Relevance 0

To test the effects of PF Ig on epidermal Dsg1, skin biopsies were collected after PF Ig treatment, and the total cellular proteins were extracted in Laemmli buffer.

Ig Regulation (effects) of Dsg1 in skin associated with bullous skin disease

4) Confidence 0.03 Published 2010 Journal Dermatology Research and Practice Section Body Doc Link PMC2902105 Disease Relevance 1.98 Pain Relevance 0

General Comments

This test has worked.