INT320794

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Context Info
Confidence 0.08
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 3.04
Pain Relevance 0.27

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (VEGFA, Flt4) extracellular space (VEGFA) growth (VEGFA)
extracellular region (VEGFA) proteinaceous extracellular matrix (VEGFA) plasma membrane (Flt4)
Anatomy Link Frequency
vasculature 1
lymphatic vessel 1
VEGFA (Homo sapiens)
Flt4 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 8 96.20 Very High Very High Very High
antagonist 5 93.60 High High
Kinase C 1 92.88 High High
cytokine 5 88.96 High High
metalloproteinase 1 16.12 Low Low
Bioavailability 1 7.32 Low Low
imagery 36 5.00 Very Low Very Low Very Low
anesthesia 7 5.00 Very Low Very Low Very Low
positron emission tomography 7 5.00 Very Low Very Low Very Low
isoflurane 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Organ Transplantation 6 99.72 Very High Very High Very High
Cancer 327 96.28 Very High Very High Very High
INFLAMMATION 7 96.20 Very High Very High Very High
Stomach Cancer 2 87.16 High High
Hematological Disease 2 87.16 High High
Prostate Cancer 2 86.08 High High
Targeted Disruption 7 84.44 Quite High
Metastasis 131 80.96 Quite High
Graft Vs Host Disease 1 31.28 Quite Low
Hypoxia 3 27.52 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
VEGFR3 binds VEGF-C and -D and is directly involved in formation of the lymphatic vasculature physiologic and tumor development [27, 28].
VEGF Binding (binds) of VEGFR3 in vasculature associated with cancer
1) Confidence 0.08 Published 2010 Journal Journal of Oncology Section Body Doc Link PMC2902148 Disease Relevance 0.49 Pain Relevance 0.05
VEGF-C, a ligand of VEGFR-3, has been shown to be able to induce lymphatic vessel growth in the cornea [9,10].
VEGF Binding (ligand) of VEGFR-3 in lymphatic vessel
2) Confidence 0.02 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2994732 Disease Relevance 0.38 Pain Relevance 0.13
On a related note, sVEGFR-3 can not only bind VEGFR-3 but also acts as a trap for VEGF-C, which blocks VEGFR-3 signaling [2,5].
VEGF Binding (trap) of VEGFR-3
3) Confidence 0.01 Published 2010 Journal BMC Med Section Body Doc Link PMC2989928 Disease Relevance 1.06 Pain Relevance 0.05
On a related note, sVEGFR-3 can not only bind VEGFR-3 but also acts as a trap for VEGF-C, which blocks VEGFR-3 signaling [2,5].
VEGF Binding (trap) of VEGFR-3
4) Confidence 0.01 Published 2010 Journal BMC Med Section Body Doc Link PMC2989928 Disease Relevance 1.11 Pain Relevance 0.05

General Comments

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