INT320827

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Context Info
Confidence 0.03
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 1.52
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (THBS1) extracellular region (THBS1) cell adhesion (THBS1)
structural molecule activity (THBS1)
Anatomy Link Frequency
bone marrow 2
THBS1 (Homo sapiens)
Pain Link Frequency Relevance Heat
imagery 1 45.76 Quite Low
cytokine 2 10.20 Low Low
dexamethasone 11 5.00 Very Low Very Low Very Low
fibrosis 1 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
peripheral neuropathy 1 5.00 Very Low Very Low Very Low
headache 1 5.00 Very Low Very Low Very Low
Potency 1 5.00 Very Low Very Low Very Low
antagonist 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Leukemia 22 96.86 Very High Very High Very High
Hematologic Neoplasms 14 92.00 High High
Solid Tumor 10 89.24 High High
Myeloid Leukemia 25 73.44 Quite High
Multiple Myeloma 33 58.08 Quite High
Disease 6 47.76 Quite Low
Disease Progression 3 33.44 Quite Low
Malignant Neoplastic Disease 4 26.64 Quite Low
Myeloproliferative Disorder 13 22.40 Low Low
Cancer 15 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
"Angiogenesis switch" in leukemia is documented by increased bone marrow MVD, increased expression of HIF-1, multiple pro-angiogenic factors (VEGF, bFGF, angiopoietin-2), soluble VEGFR, and decreased expression of endogenous angiogenesis inhibitors, such as thrombospondin-1 [50,51].
Negative_regulation (decreased) of Gene_expression (expression) of thrombospondin-1 in bone marrow associated with leukemia
1) Confidence 0.03 Published 2010 Journal J Angiogenes Res Section Body Doc Link PMC2902424 Disease Relevance 1.52 Pain Relevance 0

General Comments

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