INT320829

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Context Info
Confidence 0.45
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 2.26
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (DLL4) signal transduction (DLL4) plasma membrane (DLL4)
Anatomy Link Frequency
vasculature 3
DLL4 (Homo sapiens)
Pain Link Frequency Relevance Heat
dexamethasone 33 5.00 Very Low Very Low Very Low
cytokine 6 5.00 Very Low Very Low Very Low
fibrosis 3 5.00 Very Low Very Low Very Low
Pain 3 5.00 Very Low Very Low Very Low
peripheral neuropathy 3 5.00 Very Low Very Low Very Low
imagery 3 5.00 Very Low Very Low Very Low
headache 3 5.00 Very Low Very Low Very Low
Potency 3 5.00 Very Low Very Low Very Low
antagonist 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hypoxia 6 98.52 Very High Very High Very High
Cancer 45 92.76 High High
Pathologic Neovascularization 3 62.88 Quite High
Hematologic Neoplasms 42 60.56 Quite High
Multiple Myeloma 99 57.44 Quite High
Leukemia 66 55.04 Quite High
Myeloproliferative Disorder 39 53.84 Quite High
Fibromyalgia 3 36.96 Quite Low
Solid Tumor 30 32.24 Quite Low
Lymphatic System Cancer 12 25.44 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Disruption of Dll4 signaling by overexpression or inhibition of Dll4 may impair angiogenesis and blockade of Dll4-Notch signaling results in an increased density of nonfunctional vasculature and is associated with a reduction in the growth of human tumor xenografts [13,14].
Negative_regulation (inhibition) of Dll4 in vasculature associated with cancer
1) Confidence 0.45 Published 2010 Journal J Angiogenes Res Section Body Doc Link PMC2902424 Disease Relevance 0.95 Pain Relevance 0
Inhibition of Dll4-Notch signaling induces an increase in vessel density but these blood vessels are abnormal and not perfused [13].
Negative_regulation (Inhibition) of Dll4-Notch in blood vessels
2) Confidence 0.33 Published 2010 Journal J Angiogenes Res Section Body Doc Link PMC2902424 Disease Relevance 0.48 Pain Relevance 0
Disruption of Dll4 signaling by overexpression or inhibition of Dll4 may impair angiogenesis and blockade of Dll4-Notch signaling results in an increased density of nonfunctional vasculature and is associated with a reduction in the growth of human tumor xenografts [13,14].
Negative_regulation (Disruption) of Dll4 in vasculature associated with cancer
3) Confidence 0.33 Published 2010 Journal J Angiogenes Res Section Body Doc Link PMC2902424 Disease Relevance 0.83 Pain Relevance 0

General Comments

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