INT320831

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Context Info
Confidence 0.01
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 2.85
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

RNA binding (ZBP1) nucleus (ZBP1) DNA binding (ZBP1)
biological_process (ZBP1) cytoplasm (ZBP1)
Anatomy Link Frequency
bone marrow 2
urine 2
ZBP1 (Homo sapiens)
Pain Link Frequency Relevance Heat
imagery 2 35.04 Quite Low
cytokine 4 29.56 Quite Low
dexamethasone 22 5.00 Very Low Very Low Very Low
fibrosis 2 5.00 Very Low Very Low Very Low
Pain 2 5.00 Very Low Very Low Very Low
peripheral neuropathy 2 5.00 Very Low Very Low Very Low
headache 2 5.00 Very Low Very Low Very Low
Potency 2 5.00 Very Low Very Low Very Low
antagonist 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Leukemia 44 99.60 Very High Very High Very High
Hematologic Neoplasms 28 96.48 Very High Very High Very High
Solid Tumor 20 93.72 High High
Multiple Myeloma 66 77.44 Quite High
Disease 12 67.12 Quite High
Myeloid Leukemia 50 62.72 Quite High
Disease Progression 6 52.80 Quite High
Malignant Neoplastic Disease 8 46.00 Quite Low
Myeloproliferative Disorder 26 11.68 Low Low
Chronic Lymphoid Leukemia 2 6.32 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Moreover, it was also shown that urine and peripheral blood samples from ALL patients contained elevated levels of pro-angiogenic growth factors, namely bFGF and VEGF, which correlated with the increase of bone marrow angiogenesis [48].
Positive_regulation (elevated) of Gene_expression (levels) of factors in urine associated with leukemia
1) Confidence 0.01 Published 2010 Journal J Angiogenes Res Section Body Doc Link PMC2902424 Disease Relevance 1.36 Pain Relevance 0
"Angiogenesis switch" in leukemia is documented by increased bone marrow MVD, increased expression of HIF-1, multiple pro-angiogenic factors (VEGF, bFGF, angiopoietin-2), soluble VEGFR, and decreased expression of endogenous angiogenesis inhibitors, such as thrombospondin-1 [50,51].
Positive_regulation (increased) of Gene_expression (expression) of factors in bone marrow associated with leukemia
2) Confidence 0.01 Published 2010 Journal J Angiogenes Res Section Body Doc Link PMC2902424 Disease Relevance 1.50 Pain Relevance 0

General Comments

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