INT320840

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Context Info
Confidence 0.46
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 1.81
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Npc2) enzyme binding (Npc2) lysosome (Npc2)
Npc2 (Mus musculus)
Pain Link Frequency Relevance Heat
imagery 6 5.00 Very Low Very Low Very Low
peripheral neuropathy 2 5.00 Very Low Very Low Very Low
cINOD 2 5.00 Very Low Very Low Very Low
antiepileptic Drug 2 5.00 Very Low Very Low Very Low
medulla 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 218 91.96 High High
Epilepsy 8 84.96 Quite High
Dementia 8 83.80 Quite High
Cognitive Disorder 8 81.60 Quite High
Dysarthria 14 80.64 Quite High
Dystonia 22 80.00 Quite High
Ataxia 26 79.60 Quite High
Chorea 2 76.44 Quite High
Parkinson's Disease 2 76.12 Quite High
Movement Disorders 4 75.16 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In this model, cholesterol released within the lysosome binds to NPC2 with its hydroxyl group exposed; a transfer to the N-terminal domain of NPC1 occurs reversing its orientation, so that the hydrophobic side chain could lead the way into the membrane and/or the glycocalix.
NPC2 Binding (binds) of
1) Confidence 0.46 Published 2010 Journal Orphanet J Rare Dis Section Body Doc Link PMC2902432 Disease Relevance 0 Pain Relevance 0
The remainder have mutations in the NPC2 gene, which encodes a small soluble lysosomal protein that binds cholesterol with high affinity [16,55,56].
NPC2 Binding (binds) of
2) Confidence 0.34 Published 2010 Journal Orphanet J Rare Dis Section Body Doc Link PMC2902432 Disease Relevance 1.81 Pain Relevance 0

General Comments

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