INT320848

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Context Info
Confidence 0.39
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lysosome (Npc1, Npc2) endosome (Npc1) nuclear envelope (Npc1)
extracellular region (Npc2) Golgi apparatus (Npc1) endoplasmic reticulum (Npc1)
Npc1 (Mus musculus)
Npc2 (Mus musculus)
Pain Link Frequency Relevance Heat
imagery 3 5.00 Very Low Very Low Very Low
peripheral neuropathy 1 5.00 Very Low Very Low Very Low
cINOD 1 5.00 Very Low Very Low Very Low
antiepileptic Drug 1 5.00 Very Low Very Low Very Low
medulla 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Pick Disease Of The Brain 12 50.00 Quite Low
Disease 109 9.68 Low Low
Neurodegenerative Disease 2 9.16 Low Low
Congenital Anomalies 11 7.24 Low Low
Splenomegaly 14 5.00 Very Low Very Low Very Low
Paralysis 13 5.00 Very Low Very Low Very Low
Ataxia 13 5.00 Very Low Very Low Very Low
Sleep Disorders 13 5.00 Very Low Very Low Very Low
Dystonia 11 5.00 Very Low Very Low Very Low
Neurologic Manifestations 8 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In this model, cholesterol released within the lysosome binds to NPC2 with its hydroxyl group exposed; a transfer to the N-terminal domain of NPC1 occurs reversing its orientation, so that the hydrophobic side chain could lead the way into the membrane and/or the glycocalix.
NPC1 Binding (binds) of NPC2
1) Confidence 0.39 Published 2010 Journal Orphanet J Rare Dis Section Body Doc Link PMC2902432 Disease Relevance 0 Pain Relevance 0

General Comments

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