INT320865

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Context Info
Confidence 0.02
First Reported 2010
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 1.97
Pain Relevance 0.10

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Chi3l1) extracellular region (Chi3l1) carbohydrate metabolic process (Chi3l1)
Anatomy Link Frequency
liver 1
kidney 1
Chi3l1 (Mus musculus)
Pain Link Frequency Relevance Heat
agonist 8 100.00 Very High Very High Very High
bradykinin 2 93.08 High High
ischemia 2 27.56 Quite Low
palliative 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Colon Cancer 70 99.32 Very High Very High Very High
Metastasis 26 98.76 Very High Very High Very High
Cancer 120 97.32 Very High Very High Very High
Apoptosis 42 86.16 High High
Fibrosarcoma 2 85.24 High High
Increased Venous Pressure Under Development 2 84.64 Quite High
Pituitary Cancer 8 50.40 Quite High
Body Weight 16 29.28 Quite Low
Cv Unclassified Under Development 2 27.56 Quite Low
Pheochromocytoma 2 24.52 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This study examined the effect of AT2R activation with the agonist CGP42112A in a mouse model of CRC liver metastases.


Spec (examined) Positive_regulation (activation) of CGP42112A in liver associated with colon cancer, agonist and metastasis
1) Confidence 0.02 Published 2010 Journal Cancer Cell Int Section Abstract Doc Link PMC2902462 Disease Relevance 1.20 Pain Relevance 0.05
Activation of the AT2R (either by endogenous ligand or CGP42112A) has been shown to increase eNOS levels in the developing pig [32] and nNOS in the rat kidney[33].
Positive_regulation (Activation) of CGP42112A in kidney
2) Confidence 0.02 Published 2010 Journal Cancer Cell Int Section Body Doc Link PMC2902462 Disease Relevance 0.76 Pain Relevance 0.05

General Comments

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