INT320985

Context Info Confidence 0.37 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 2 Disease Relevance 1.26 Pain Relevance 0.08

extracellular space (Pth)

Anatomy Link Frequency parathyroid 2 Pth (Mus musculus)

Pain Link Frequency Relevance Heat Pain 2 82.64 tolerance 2 5.00 fibrosis 2 5.00

Disease Link Frequency Relevance Heat Hypercalcemia 12 99.96 Rickets 16 94.80 Pain 2 82.64 Muscle Weakness 4 82.16 Frailty 6 77.60 Mobility Limitation 2 76.32 Tetany 2 67.44 Convulsion 2 66.64 Systemic Lupus Erythematosus 12 50.00 Sunburn 2 48.96

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

In mild vitamin D deficiency, the elevation of serum PTH increases the conversion of 25(OH)D to 1,25(OH)D to compensate for the insufficient 25(OH)D available; however, elevation in PTH increases bone resorption, leading to additional bone loss [19].

Positive_regulation (increases) of Localization (elevation) of PTH associated with hypercalcemia

1) Confidence 0.37 Published 2010 Journal Curr Rheumatol Rep Section Body Doc Link PMC2902729 Disease Relevance 1.10 Pain Relevance 0.08

The reduction in intestinal calcium absorption associated with low levels of vitamin D triggers the release of parathyroid hormone (PTH), which stimulates the absorption of calcium through augmentation of the production of 1,25(OH)2D [2, 3].

Positive_regulation (triggers) of Localization (release) of parathyroid hormone in parathyroid

2) Confidence 0.35 Published 2010 Journal Curr Rheumatol Rep Section Body Doc Link PMC2902729 Disease Relevance 0.16 Pain Relevance 0

General Comments

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