INT320992

Context Info Confidence 0.50 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 5 Total Number 6 Disease Relevance 4.23 Pain Relevance 0.73

extracellular space (Pecam1) cell adhesion (Pecam1) plasma membrane (Pecam1)

Anatomy Link Frequency plug 4 neutrophils 3 lymphocytes 1 Pecam1 (Mus musculus)

Pain Link Frequency Relevance Heat ischemia 108 98.44 Inflammation 60 84.32 antagonist 24 76.32 Hippocampus 32 51.76 Central nervous system 4 50.00 Pyramidal cell 8 35.20 rheumatoid arthritis 8 5.00 anesthesia 6 5.00 isoflurane 6 5.00 cytokine 4 5.00

Disease Link Frequency Relevance Heat Cv Unclassified Under Development 84 98.44 Myocardial Infarction 140 97.68 Obesity 8 96.64 Stroke 10 91.24 INFLAMMATION 58 84.32 Disease 24 79.44 Adhesions 10 78.40 Stress 102 74.16 Death 20 65.68 Cv General 4 Under Development 4 62.24

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Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

The elevation of PECAM-1 in vessels is known to increase the transmigration of lymphocytes and neutrophils (Dangerfield et al., 2002; Michiels et al., 1998).

Positive_regulation (increase) of Positive_regulation (elevation) of PECAM-1 in neutrophils

1) Confidence 0.50 Published 2010 Journal Anatomy & Cell Biology Section Body Doc Link PMC2998780 Disease Relevance 1.28 Pain Relevance 0.31

Flow cytometric analysis showing a significant increase of LacZ+ cells in both Sca-1+ (b) and CD31+ (d) cell populations, parallel with an increase in total Sca+ (a) and CD31+ (c) cell numbers.

Positive_regulation (increase) of Positive_regulation (increase) of CD31

2) Confidence 0.30 Published 2010 Journal Basic Res Cardiol Section Body Doc Link PMC2916122 Disease Relevance 0.81 Pain Relevance 0

Flow cytometric analysis indeed displayed a significant increase of LacZ+ cells in both Sca-1+ and CD31+ cell populations, parallel with an increase in total Sca+ and CD31+ cell numbers (Fig. 5a–d).

Positive_regulation (increase) of Positive_regulation (increase) of CD31

3) Confidence 0.30 Published 2010 Journal Basic Res Cardiol Section Body Doc Link PMC2916122 Disease Relevance 0.43 Pain Relevance 0

The elevation of PECAM-1 in vessels is known to increase the transmigration of lymphocytes and neutrophils (Dangerfield et al., 2002; Michiels et al., 1998).

Positive_regulation (increase) of in lymphocytes Positive_regulation (elevation) of PECAM-1 in neutrophils

4) Confidence 0.17 Published 2010 Journal Anatomy & Cell Biology Section Body Doc Link PMC2998780 Disease Relevance 1.28 Pain Relevance 0.31

However, the addition of FGF-2 or C5a induced accumulation of CD31+ endothelial cells in the plugs and subsequent formation of microvascular-like structure (Fig. 7e–h).

Positive_regulation (induced) of Positive_regulation (accumulation) of CD31 in plugs

5) Confidence 0.09 Published 2010 Journal Inflamm Res Section Body Doc Link PMC2902742 Disease Relevance 0.09 Pain Relevance 0

In our experiments, the Matrigel plug containing C5a or FGF-2 showed increased accumulation of CD31+ endothelial cells and microvascular-like structure formation with infiltration of adipocytes.

Positive_regulation (increased) of Positive_regulation (accumulation) of CD31 in plug associated with obesity

6) Confidence 0.09 Published 2010 Journal Inflamm Res Section Body Doc Link PMC2902742 Disease Relevance 0.35 Pain Relevance 0.10

General Comments

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