INT321018

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Context Info
Confidence 0.14
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 4
Disease Relevance 0.52
Pain Relevance 2.73

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Ptpn6) phosphatase activity (Ptpn6) cell proliferation (Ptpn6)
nucleus (Ptpn6) cytoplasm (Ptpn6)
Ptpn6 (Mus musculus)
Pain Link Frequency Relevance Heat
Central nervous system 20 97.20 Very High Very High Very High
Opioid 96 92.24 High High
narcan 84 91.16 High High
addiction 16 88.32 High High
Acute pain 4 88.32 High High
Morphine 56 85.12 High High
antinociception 108 84.44 Quite High
Spinal cord 24 84.44 Quite High
opioid receptor 152 78.16 Quite High
antagonist 28 76.92 Quite High
Disease Link Frequency Relevance Heat
Pain 56 88.32 High High
Targeted Disruption 12 77.68 Quite High
Toxicity 8 76.56 Quite High
Hyperalgesia 8 54.48 Quite High
Brain Hemorrhage 4 53.20 Quite High
Syndrome 12 51.64 Quite High
Nociception 20 47.76 Quite Low
Neuropathic Pain 12 37.76 Quite Low
Disease 12 32.64 Quite Low
Stress 4 21.88 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This effect of ME was markedly potentiated by addition of the mixture of peptidase inhibitors owing to the inhibition of the degradation of ME.
Protein_catabolism (degradation) of ME
1) Confidence 0.14 Published 2010 Journal Frontiers in Neuroscience Section Body Doc Link PMC2903224 Disease Relevance 0.19 Pain Relevance 0.63
It was also proved that ME hydrolyzing enzymes were involved in the degradation of not only ME but also ?
Protein_catabolism (degradation) of ME
2) Confidence 0.14 Published 2010 Journal Frontiers in Neuroscience Section Body Doc Link PMC2903224 Disease Relevance 0.05 Pain Relevance 1.09
Later on, Anderson et al. (1998) also supported the theory employing different experimental systems, in which ME was proven to be most readily degraded by the oligopeptidases contained in the venom of the Taiwan cobra, releasing a steady accumulation of Tyr, Gly–Gly and Phe–Met over time.
Protein_catabolism (degraded) of ME
3) Confidence 0.11 Published 2010 Journal Frontiers in Neuroscience Section Body Doc Link PMC2903224 Disease Relevance 0.06 Pain Relevance 0.54
As it is already widely accepted, APN accounts for several biologically active peptides’ degradation, such as ME, LE, ?
Protein_catabolism (degradation) of ME
4) Confidence 0.08 Published 2010 Journal Frontiers in Neuroscience Section Body Doc Link PMC2903224 Disease Relevance 0.22 Pain Relevance 0.47

General Comments

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