INT321023

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Context Info
Confidence 0.07
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 0.27
Pain Relevance 2.15

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Ptpn6) phosphatase activity (Ptpn6) cell proliferation (Ptpn6)
nucleus (Ptpn6) cytoplasm (Ptpn6)
Anatomy Link Frequency
spinal 2
EM-2 2
Ptpn6 (Mus musculus)
Pain Link Frequency Relevance Heat
Dynorphin 60 100.00 Very High Very High Very High
antinociception 81 99.48 Very High Very High Very High
Pain 21 94.56 High High
Spinal cord 18 93.12 High High
narcan 63 91.76 High High
Opioid 72 89.96 High High
tail-flick 27 87.04 High High
antagonist 21 85.12 High High
Pain threshold 9 82.08 Quite High
Antinociceptive 63 76.44 Quite High
Disease Link Frequency Relevance Heat
Pain 42 94.56 High High
Nociception 15 90.28 High High
Syndrome 9 5.00 Very Low Very Low Very Low
Targeted Disruption 9 5.00 Very Low Very Low Very Low
Disease 9 5.00 Very Low Very Low Very Low
Neuropathic Pain 9 5.00 Very Low Very Low Very Low
Hyperalgesia 6 5.00 Very Low Very Low Very Low
Toxicity 6 5.00 Very Low Very Low Very Low
Injury 6 5.00 Very Low Very Low Very Low
Leukemia 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Further research implied that the antinociception induced by EM-2 might be mediated by the release of Dyn A1–17 and ME, which subsequently acted on KORs and DORs to produce antinociception (Tseng et al., 2000; Sakurada et al., 2001).
Positive_regulation (mediated) of Localization (release) of ME in EM-2 associated with antinociception and dynorphin
1) Confidence 0.07 Published 2010 Journal Frontiers in Neuroscience Section Body Doc Link PMC2903224 Disease Relevance 0.27 Pain Relevance 0.62
-EP injected into the fourth ventricle could increase immunoreactive ME in the spinal perfusate in urethane-anesthetized rats; furthermore, Bestatin increased the amount of immunoreactive ME released by ?
Positive_regulation (increased) of Localization (released) of ME in spinal
2) Confidence 0.06 Published 2010 Journal Frontiers in Neuroscience Section Body Doc Link PMC2903224 Disease Relevance 0 Pain Relevance 0.77
-EP was mediated by release of ME.
Positive_regulation (mediated) of Localization (release) of ME
3) Confidence 0.06 Published 2010 Journal Frontiers in Neuroscience Section Body Doc Link PMC2903224 Disease Relevance 0 Pain Relevance 0.76

General Comments

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