INT32107

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Context Info
Confidence 0.47
First Reported 1989
Last Reported 2010
Negated 3
Speculated 0
Reported most in Body
Documents 14
Total Number 14
Disease Relevance 8.06
Pain Relevance 6.76

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (PTPLA) lyase activity (PTPLA) endoplasmic reticulum (PTPLA)
Anatomy Link Frequency
germ cells 2
cochlear 1
SNU-1 1
PTPLA (Homo sapiens)
Pain Link Frequency Relevance Heat
qutenza 445 100.00 Very High Very High Very High
abdominal pain 44 100.00 Very High Very High Very High
cva 10 99.90 Very High Very High Very High
antagonist 5 99.56 Very High Very High Very High
Dopamine 6 99.28 Very High Very High Very High
agonist 53 99.22 Very High Very High Very High
Cannabinoid receptor 10 99.14 Very High Very High Very High
Pain 45 98.08 Very High Very High Very High
nociceptor 13 96.24 Very High Very High Very High
TRP channel 3 95.92 Very High Very High Very High
Disease Link Frequency Relevance Heat
Abdominal Pain 44 100.00 Very High Very High Very High
Pneumonia 19 100.00 Very High Very High Very High
Cv General 3 Under Development 10 99.90 Very High Very High Very High
Cancer 31 98.96 Very High Very High Very High
Pain 56 98.08 Very High Very High Very High
Apoptosis 110 97.36 Very High Very High Very High
Hypersensitivity 3 96.20 Very High Very High Very High
Neuralgia 4 95.76 Very High Very High Very High
Herpes Simplex Virus Infection 4 95.36 Very High Very High Very High
Anaphylaxis 5 95.12 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Campylobacter pylori was cultured from the two ELISA-negative but infected patients and these isolates did possess HM-CAP antigens, showing that these two individuals had failed to seroconvert.
Gene_expression (possess) of HM-CAP
1) Confidence 0.47 Published 1989 Journal Gastroenterology Section Abstract Doc Link 2925047 Disease Relevance 0.63 Pain Relevance 0.10
Among the most relevant, we identified a) processes of remodeling and organization of actin (WDR1, CLRN1, FLII), an essential component of the hair-cell bundle; b) formation and maintenance of cilia (ALMS1, USH1G, CC2D2A), the sensory organelles devoted to receive the mechanical stimulus; c) cycling and pH homeostasis in cochlear fluids (ATP6V0A4, KCNQ1, KCNE1L), essentials for the generation and maintenance of the endocochlear potential; d) signal transduction (PTPLA, PTPN11, TBL1X, TIMM8A).
Gene_expression (transduction) of PTPLA in cochlear
2) Confidence 0.41 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2946934 Disease Relevance 0.35 Pain Relevance 0
Consequently, SNU-1 cells are sensitive to CAP in the overexpression of tumor suppressor gene, p53 and proto-oncogenes, c-myc and c-Ha-ras, but not those of c-erbB-2, c-jun and bcl-2 genes.
Neg (not) Gene_expression (sensitive) of CAP in SNU-1 associated with qutenza and cancer
3) Confidence 0.25 Published 1997 Journal Cancer Lett. Section Abstract Doc Link 9461043 Disease Relevance 1.15 Pain Relevance 1.00
The mixed CB1 and TRPV1 antagonist, AM251, enhanced the CAP-induced rise in IL-8 release to a higher level than that elicited by CAP alone.
Gene_expression (rise) of CAP-induced associated with cannabinoid receptor and antagonist
4) Confidence 0.25 Published 2010 Journal Exp. Eye Res. Section Abstract Doc Link 20619260 Disease Relevance 0.06 Pain Relevance 0.58
Although the present and our previous study are not comparable as different models (mice versus rat, in vivo versus in vitro) and different TRPV1 agonists were used, it is indeed possible that CAP bypasses TRPV1 in the cultured cells.
Gene_expression (bypasses) of CAP associated with qutenza and agonist
5) Confidence 0.25 Published 2008 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2588595 Disease Relevance 0.54 Pain Relevance 0.47
TRPV1, the receptor for CAP, was found to be expressed by the spermatogonial stem cells in vitro and also by premeiotic germ cells in situ.


Gene_expression (expressed) of CAP in germ cells associated with qutenza
6) Confidence 0.22 Published 2008 Journal Reprod Biol Endocrinol Section Abstract Doc Link PMC2588595 Disease Relevance 0.23 Pain Relevance 0.77
In addition we show that the cell lines used and the germ cells from which the cell lines originated express the CAP receptor, TRPV1.
Gene_expression (express) of CAP in germ cells associated with qutenza
7) Confidence 0.22 Published 2008 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2588595 Disease Relevance 0.40 Pain Relevance 0.51
M CAP solution or with 1 ?
Gene_expression (solution) of CAP associated with qutenza
8) Confidence 0.21 Published 2008 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2588595 Disease Relevance 0.08 Pain Relevance 0.27
Angina pectoris may present as CAP, especially postprandially.
Gene_expression (present) of CAP associated with abdominal pain and cva
9) Confidence 0.21 Published 2008 Journal Cases J Section Body Doc Link PMC2556666 Disease Relevance 2.22 Pain Relevance 1.24
Capsaicin (CAP), N-arachidonoyl-dopamine (NADA), agonists of TRPV1, capsazepine, a well characterized antagonist of TRPV1, and ionomycin (IONO), a calcium ionophore, were dissolved in DMSO (all from Sigma-Aldrich, St.
Gene_expression (Capsaicin) of CAP associated with dopamine, qutenza, antagonist and agonist
10) Confidence 0.11 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2566593 Disease Relevance 0.27 Pain Relevance 0.70
The dose of CAP concentrations causing non TRPV1 mediated cytotoxicity was ?
Gene_expression (concentrations) of CAP associated with qutenza
11) Confidence 0.11 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2566593 Disease Relevance 0.06 Pain Relevance 0.29
Indeed, avian seed dispersers are favored, whereas, mammalian herbivores are repelled by plants producing fruits with CAP or other toxic vanilloids [3].
Gene_expression (producing) of CAP associated with qutenza
12) Confidence 0.10 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2566593 Disease Relevance 0.28 Pain Relevance 0.74
However, the positive effect of PCV-7 on CAP prevention was greater than that previously reported with this vaccine [19] and similar to that observed with the 9-valent pneumococcal vaccine [38].
Neg (prevention) Gene_expression (prevention) of CAP associated with pneumonia
13) Confidence 0.03 Published 2007 Journal Respir Res Section Body Doc Link PMC1804265 Disease Relevance 0.66 Pain Relevance 0
Furthermore, in two patients ImmunoCAP to rPru p 1, rPru p 3, and rPru p 4 were negative.
Neg (negative) Gene_expression (negative) of ImmunoCAP
14) Confidence 0.02 Published 2009 Journal Arerugi Section Abstract Doc Link 19329877 Disease Relevance 1.12 Pain Relevance 0.08

General Comments

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