INT32113

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Context Info
Confidence 0.58
First Reported 1989
Last Reported 2007
Negated 0
Speculated 0
Reported most in Abstract
Documents 6
Total Number 6
Disease Relevance 0
Pain Relevance 0.70

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Prep) peptidase activity (Prep) nucleus (Prep)
cytoplasm (Prep)
Anatomy Link Frequency
VMH 6
Prep (Rattus norvegicus)
Pain Link Frequency Relevance Heat
alcohol 12 98.04 Very High Very High Very High
Endogenous opioid 2 71.48 Quite High
Opioid 2 63.36 Quite High
Anterior cingulate cortex 35 53.84 Quite High
Pyramidal cell 31 52.56 Quite High
Enkephalin 7 25.00 Low Low
Dopamine 6 5.00 Very Low Very Low Very Low
amygdala 5 5.00 Very Low Very Low Very Low
ketamine 2 5.00 Very Low Very Low Very Low
cerebral cortex 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Stress 80 18.16 Low Low
Body Weight 15 5.00 Very Low Very Low Very Low
Anxiety Disorder 4 5.00 Very Low Very Low Very Low
Disseminated Intravascular Coagulation 2 5.00 Very Low Very Low Very Low
Overdose 1 5.00 Very Low Very Low Very Low
Schizophrenia 1 5.00 Very Low Very Low Very Low
Frailty 1 5.00 Very Low Very Low Very Low
Cognitive Disorder 1 5.00 Very Low Very Low Very Low
Decapitation 1 5.00 Very Low Very Low Very Low
Depression 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Overall, these data indicate that the estrogen responsiveness of PE mRNA expression in the VMN declines with age and, furthermore, prenatal exposure to alcohol blunts estrogen's effects on PE mRNA expression in the adult VMN.
Negative_regulation (declines) of Gene_expression (expression) of PE mRNA in VMN associated with alcohol
1) Confidence 0.58 Published 1997 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 9221919 Disease Relevance 0 Pain Relevance 0.19
Following estrogen removal the levels of PE mRNA declined rapidly.
Negative_regulation (declined) of Gene_expression (levels) of PE mRNA
2) Confidence 0.42 Published 1989 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 2927283 Disease Relevance 0 Pain Relevance 0
Film autoradiogram density, numbers of PE mRNA-expressing cells and exposed silver grains/cell were analyzed.
Negative_regulation (numbers) of Gene_expression (expressing) of PE mRNA
3) Confidence 0.37 Published 1997 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 9221919 Disease Relevance 0 Pain Relevance 0.19
Furthermore, gonadectomy reduced PE mRNA expression in the VMH, but not in the striatum nor the olfactory tubercle compared to intact rats, and this reduction was prevented in the presence of E2, but not DHT.
Negative_regulation (reduced) of Gene_expression (expression) of PE mRNA in VMH
4) Confidence 0.12 Published 1993 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 8361335 Disease Relevance 0 Pain Relevance 0.13
Furthermore, gonadectomy reduced PE mRNA expression in the VMH, but not in the striatum nor the olfactory tubercle compared to intact rats, and this reduction was prevented in the presence of E2, but not DHT.
Negative_regulation (reduced) of Gene_expression (expression) of PE mRNA in VMH
5) Confidence 0.09 Published 1993 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 8361335 Disease Relevance 0 Pain Relevance 0.13
Bonferroni's post hoc test showed reliable
Negative_regulation (showed) of Gene_expression (test) of post
6) Confidence 0.03 Published 2007 Journal Neural Plasticity Section Body Doc Link PMC1975761 Disease Relevance 0 Pain Relevance 0.05

General Comments

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