INT321170

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Context Info
Confidence 0.29
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.20
Pain Relevance 0.25

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

unfolded protein binding (Hsp90aa1) protein folding (Hsp90aa1) cytosol (Hsp90aa1)
ATPase activity (Hsp90aa1) intracellular (Hsp90aa1) response to stress (Hsp90aa1)
Hsp90aa1 (Mus musculus)
Pain Link Frequency Relevance Heat
agonist 36 76.40 Quite High
alcohol 4 64.64 Quite High
Hippocampus 6 57.12 Quite High
antidepressant 20 16.68 Low Low
Glutamate 12 5.00 Very Low Very Low Very Low
Eae 10 5.00 Very Low Very Low Very Low
Nerve growth factor 8 5.00 Very Low Very Low Very Low
depression 6 5.00 Very Low Very Low Very Low
ischemia 6 5.00 Very Low Very Low Very Low
trk B 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Shock 12 99.16 Very High Very High Very High
Targeted Disruption 20 9.04 Low Low
Apoptosis 32 5.64 Low Low
Anxiety Disorder 46 5.00 Very Low Very Low Very Low
Ganglion Cysts 16 5.00 Very Low Very Low Very Low
Death 8 5.00 Very Low Very Low Very Low
Neurological Disease 8 5.00 Very Low Very Low Very Low
Stroke 8 5.00 Very Low Very Low Very Low
Depression 6 5.00 Very Low Very Low Very Low
Neurodegenerative Disease 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Gedunin, a tetranortriterpenoid isolated from the Indian neem tree (Azadirachta indica), and was recently shown to manifest anticancer activity via inhibition of the 90 kDa heat shock protein (Hsp90) folding machinery and to induce the degradation of Hsp90-dependent client proteins similar to other Hsp90 inhibitors [20], [21], [22], [23], [40].
Positive_regulation (induce) of Protein_catabolism (degradation) of Hsp90-dependent associated with shock
1) Confidence 0.29 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2903477 Disease Relevance 0.10 Pain Relevance 0.12
Gedunin, a tetranortriterpenoid isolated from the Indian neem tree (Azadirachta indica), and was recently shown to manifest anticancer activity via inhibition of the 90 kDa heat shock protein (Hsp90) folding machinery and to induce the degradation of Hsp90-dependent client proteins similar to other Hsp90 inhibitors [20], [21], [22], [23], [40].
Positive_regulation (induce) of Protein_catabolism (degradation) of Hsp90 associated with shock
2) Confidence 0.29 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2903477 Disease Relevance 0.10 Pain Relevance 0.13

General Comments

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