INT321181

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Context Info
Confidence 0.09
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.08
Pain Relevance 0.14

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Ntrk2) cytosol (Ntrk2) extracellular region (Ntf5)
plasma membrane (Ntrk2) kinase activity (Ntrk2)
Anatomy Link Frequency
neurons 1
Ntrk2 (Mus musculus)
Ntf5 (Mus musculus)
Pain Link Frequency Relevance Heat
Nerve growth factor 4 99.50 Very High Very High Very High
Glutamate 6 40.24 Quite Low
agonist 18 5.00 Very Low Very Low Very Low
antidepressant 10 5.00 Very Low Very Low Very Low
Eae 5 5.00 Very Low Very Low Very Low
depression 3 5.00 Very Low Very Low Very Low
ischemia 3 5.00 Very Low Very Low Very Low
Hippocampus 3 5.00 Very Low Very Low Very Low
trk B 2 5.00 Very Low Very Low Very Low
Pain 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Neurological Disease 4 78.64 Quite High
Toxicity 1 39.44 Quite Low
Apoptosis 16 35.84 Quite Low
Injury 2 31.52 Quite Low
Neurodegenerative Disease 3 12.96 Low Low
Motor Neuron Diseases 1 6.88 Low Low
Anxiety Disorder 23 5.00 Very Low Very Low Very Low
Targeted Disruption 10 5.00 Very Low Very Low Very Low
Ganglion Cysts 8 5.00 Very Low Very Low Very Low
Shock 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Neurotrophins exert their biological functions on neurons through two transmembrane receptors: the p75 neurotrophin receptor (p75NTR) and the Trk receptor tyrosine kinases (NGF binds to TrkA, BDNF and NT-4/5 bind to TrkB, and NT-3 preferentially binds to TrkC) [3], [4].
TrkB Binding (bind) of NT-4 in neurons associated with nerve growth factor
1) Confidence 0.09 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2903477 Disease Relevance 0.08 Pain Relevance 0.14

General Comments

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