INT32124

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Context Info
Confidence 0.37
First Reported 1981
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 10
Total Number 11
Disease Relevance 6.53
Pain Relevance 3.81

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
ECs 1
plasma 1
cleavage 1
posterior 1
ETS 1
ecs (Mus musculus)
Pain Link Frequency Relevance Heat
antidepressant 8 100.00 Very High Very High Very High
narcan 15 98.80 Very High Very High Very High
Opioid 5 98.72 Very High Very High Very High
Clonidine 4 97.80 Very High Very High Very High
analgesia 10 96.40 Very High Very High Very High
Somatostatin 2 96.20 Very High Very High Very High
Deafferentation 2 95.96 Very High Very High Very High
monoamine 2 94.88 High High
antagonist 4 93.12 High High
depression 2 89.44 High High
Disease Link Frequency Relevance Heat
Shock 38 100.00 Very High Very High Very High
Apoptosis 58 99.98 Very High Very High Very High
Catalepsy 2 99.96 Very High Very High Very High
Convulsion 9 99.28 Very High Very High Very High
Amnesia 4 99.20 Very High Very High Very High
Sleep Disorders 1 96.64 Very High Very High Very High
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super

5 96.50 Very High Very High Very High
Epilepsy 2 94.36 High High
Reprotox - General 3 2 90.92 High High
Depression 3 89.44 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Both repeated ECS and antidepressant drug administration decrease cortical beta-adrenoceptor density and attenuate the alpha 2-adrenoceptor-mediated sedation response to clonidine injection.
Negative_regulation (decrease) of ECS associated with antidepressant, shock, sleep disorders and clonidine
1) Confidence 0.37 Published 1986 Journal Ciba Found. Symp. Section Abstract Doc Link 3028726 Disease Relevance 0.52 Pain Relevance 0.43
However, the maximally tolerable pressures determined in the D-IBS subjects were significantly lower than those of the control subjects (P < 0.01), and we detected a significant relationship between the maximally tolerable pressures and the numbers of ECs in the rectum (r = -0.37, P < 0.01).
Negative_regulation (numbers) of ECs in ECs
2) Confidence 0.36 Published 2006 Journal Neurogastroenterol. Motil. Section Abstract Doc Link 16771769 Disease Relevance 0.43 Pain Relevance 0.26
To assess the potential loss of SSergic hilar neurons after repeated ECS, 10 rats were given 110 ECS, one per day, 5 days a week.
Negative_regulation (loss) of ECS in neurons
3) Confidence 0.36 Published 1996 Journal Biol. Psychiatry Section Abstract Doc Link 8780855 Disease Relevance 0.53 Pain Relevance 0.22
The amnestic effect of ECS was observed in all groups except in the one with the posterior hypothalamic lesion.
Negative_regulation (effect) of ECS in posterior
4) Confidence 0.35 Published 1985 Journal Psychoneuroendocrinology Section Abstract Doc Link 2930863 Disease Relevance 0.16 Pain Relevance 0.15
One single active escape trial preceding ECS prevented ECS-interference with the subsequent acquisition of the task.
Negative_regulation (prevented) of ECS associated with shock
5) Confidence 0.30 Published 1986 Journal Physiol. Behav. Section Abstract Doc Link 3823168 Disease Relevance 0.89 Pain Relevance 0.16
In contrast, catalepsy measured in the same animals was not affected by 1 mg/kg of naloxone but increasing the dose to 10 mg/kg produced a significant attenuation of ECS catalepsy.
Negative_regulation (attenuation) of ECS associated with catalepsy, shock and narcan
6) Confidence 0.13 Published 1982 Journal Eur. J. Pharmacol. Section Abstract Doc Link 6889535 Disease Relevance 0.82 Pain Relevance 1.86
1's anti-apoptotic effect on ECs, we examined cleavage of caspase 3, a key step in the apoptotic cascade, and the BCl-2 family of proteins, which also plays a role in apoptosis.
Negative_regulation (effect) of ECs in cleavage associated with apoptosis
7) Confidence 0.13 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2659748 Disease Relevance 0.98 Pain Relevance 0
Nuclear condensation associated with apoptosis was apparent in some, but not all pericytes (Figure 7C) and ECs (Figure D), and, consistent with our findings of non-perfusion and impaired NO formation in sEng expressing mice, many vessels appeared completely or partially collapsed (Figures 7E and 7F).


Negative_regulation (apparent) of ECs in vessels associated with apoptosis
8) Confidence 0.13 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2659748 Disease Relevance 0.48 Pain Relevance 0
On test session (24 h later) MRN-lesioned rats presented a longer conditioned response and, chiefly, a remarkable reduction of ECS-induced retrograde amnesia in comparison to sham-lesioned animals.
Negative_regulation (reduction) of ECS in MRN associated with shock and amnesia
9) Confidence 0.12 Published 1981 Journal Neuropsychobiology Section Abstract Doc Link 6969865 Disease Relevance 0.75 Pain Relevance 0.15
B (intraventricular injection 20 ng/kg decreased the amplitude of NP20-40 EP to ECS, but not to ETS.
Negative_regulation (decreased) of ECS in ETS
10) Confidence 0.08 Published 1988 Journal Physiol Bohemoslov Section Abstract Doc Link 2975796 Disease Relevance 0.07 Pain Relevance 0.21
The plasma GH response to ICI 118,551 was apparently decreased 1 and 7 days after the seventh ECS.
Negative_regulation (decreased) of ECS in plasma
11) Confidence 0.05 Published 1982 Journal Psychopharmacology (Berl.) Section Abstract Doc Link 6126899 Disease Relevance 0.47 Pain Relevance 0.37

General Comments

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