INT3213

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.76
First Reported 1978
Last Reported 2011
Negated 5
Speculated 7
Reported most in Body
Documents 511
Total Number 523
Disease Relevance 357.59
Pain Relevance 53.32

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Ins1) extracellular region (Ins1) carbohydrate metabolic process (Ins1)
cytoplasm (Ins1)
Anatomy Link Frequency
liver 43
plasma 42
blood 27
skeletal muscle 19
beta cells 15
Ins1 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 3844 100.00 Very High Very High Very High
tolerance 2247 100.00 Very High Very High Very High
electroacupuncture 1230 99.98 Very High Very High Very High
antagonist 544 99.92 Very High Very High Very High
Somatostatin 273 99.92 Very High Very High Very High
substance P 31 99.92 Very High Very High Very High
Opioid 70 99.84 Very High Very High Very High
Spinal cord 42 99.84 Very High Very High Very High
Inflammatory mediators 87 99.80 Very High Very High Very High
Clonidine 50 99.78 Very High Very High Very High
Disease Link Frequency Relevance Heat
Insulin Resistance 6853 100.00 Very High Very High Very High
INFLAMMATION 4182 100.00 Very High Very High Very High
Targeted Disruption 3716 100.00 Very High Very High Very High
Impaired Glucose Tolerance 1844 100.00 Very High Very High Very High
Hyperinsulinism 1020 100.00 Very High Very High Very High
Frailty 220 100.00 Very High Very High Very High
Chronic Renal Failure 133 100.00 Very High Very High Very High
Repression 41 100.00 Very High Very High Very High
Hepatotoxicity 18 100.00 Very High Very High Very High
Metabolic Syndrome 1608 99.96 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It appears that the changes in serum insulin level produced by various treatments may have a relationship with the antinociceptive response.
Gene_expression (produced) of insulin associated with antinociceptive
1) Confidence 0.76 Published 2001 Journal Indian J. Exp. Biol. Section Abstract Doc Link 11883508 Disease Relevance 0.34 Pain Relevance 0.38
-catenin expression, insulin and glucagon cells were present and normally distributed within the islets [Fig 3A–F].
Gene_expression (expression) of insulin
2) Confidence 0.72 Published 2007 Journal BMC Dev Biol Section Body Doc Link PMC1783845 Disease Relevance 0.32 Pain Relevance 0.15
A higher dose of U 50488h (10 mg/kg body wt i.p.) was required to produce significant increases in lean mouse plasma insulin (81 pM at 15 min) and glucose (0.7, 1.1, and 1.7 mM at 5, 15, and 30 min, respectively).
Gene_expression (produce) of insulin in plasma
3) Confidence 0.67 Published 1990 Journal Diabetes Section Abstract Doc Link 1976559 Disease Relevance 0.32 Pain Relevance 0.35
In ob/ob mice, the agonist-induced rise in glucose did not cause the insulin response, because insulin levels were not elevated by a glucose challenge.
Gene_expression (levels) of insulin associated with obesity and agonist
4) Confidence 0.67 Published 1990 Journal Diabetes Section Abstract Doc Link 1976559 Disease Relevance 0.31 Pain Relevance 0.21
In type 1 diabetes, T cell-mediated death of pancreatic beta cells produces insulin deficiency.
Gene_expression (produces) of insulin in pancreatic beta cells associated with diabetes mellitus and death
5) Confidence 0.66 Published 2006 Journal Cell Section Abstract Doc Link 17174891 Disease Relevance 1.00 Pain Relevance 0.11
This study examines the effects of a relatively selective alpha 2-adrenoceptor antagonist, 8-(L-piperazinyl)imado-[1,2-alpha] pyrazine (compound A), and the preferential alpha 2-agonist clonidine on blood glucose, glucose tolerance, and plasma insulin levels in the C57BL/6J ob/ob mouse and its lean littermate.
Gene_expression (levels) of insulin in plasma associated with antagonist, obesity, tolerance, agonist, impaired glucose tolerance and clonidine
6) Confidence 0.65 Published 1990 Journal Metab. Clin. Exp. Section Abstract Doc Link 1970847 Disease Relevance 0.74 Pain Relevance 0.71
Furthermore, M35 displaced 125I-monoiodo-[Tyr26]galanin from membranes of insulin producing RINm5F cells.
Gene_expression (producing) of insulin
7) Confidence 0.65 Published 1993 Journal Eur. J. Pharmacol. Section Abstract Doc Link 7681407 Disease Relevance 0.07 Pain Relevance 0.40
In conclusion, M35 is a specific, non-methionine-containing galanin receptor antagonist on insulin-producing cells.
Gene_expression (producing) of insulin associated with antagonist
8) Confidence 0.65 Published 1993 Journal Eur. J. Pharmacol. Section Abstract Doc Link 7681407 Disease Relevance 0.05 Pain Relevance 0.34
These observations suggest that the alpha 2-antagonist studied, increased plasma insulin levels with an accompanying reduction in blood glucose and an improvement in glucose tolerance in a genetic model of insulin resistance.
Gene_expression (resistance) of insulin in blood associated with antagonist, tolerance, insulin resistance and impaired glucose tolerance
9) Confidence 0.65 Published 1990 Journal Metab. Clin. Exp. Section Abstract Doc Link 1970847 Disease Relevance 0.85 Pain Relevance 0.75
S1, G and H) indicate that the absence of leptin affects circulating insulin levels primarily by regulating insulin expression and secretion in addition to the possibility of changes of cell survival.
Gene_expression (expression) of insulin
10) Confidence 0.63 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2606962 Disease Relevance 0.67 Pain Relevance 0
Expression of the Insulin genes and of Glucokinase, a central component of the glucose-sensing machinery of ?
Gene_expression (Expression) of Insulin
11) Confidence 0.63 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2606962 Disease Relevance 0.89 Pain Relevance 0
Expression of Insulin, Glucokinase, and Cdk4 was up-regulated to the same extent in islets of adipocyte-deficient and ob/ob mice (Fig. 1 H), and insulin content was significantly increased in islets of adipocyte-deficient mice (Fig.
Gene_expression (Expression) of Insulin in adipocyte associated with obesity
12) Confidence 0.63 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2606962 Disease Relevance 0.72 Pain Relevance 0
In addition, expression of Insulin and Glucokinase in isolated islets (Fig. 3 H) was induced by osteocalcin in a time- and dose-dependent manner.
Gene_expression (expression) of Insulin
13) Confidence 0.63 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2606962 Disease Relevance 0.40 Pain Relevance 0.04
Osteocalcin acts in this context primarily by regulating insulin expression and secretion.
Gene_expression (expression) of insulin
14) Confidence 0.63 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2606962 Disease Relevance 0.38 Pain Relevance 0
Second, the low affinity fractions regulated Insulin expression in isolated islets, whereas the ones binding to HA with high affinity did not (Fig. 3 D).
Gene_expression (expression) of Insulin
15) Confidence 0.63 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2606962 Disease Relevance 0 Pain Relevance 0.03
The higher food intake in the HFL fed animals per sé may induce insulin resistance.
Gene_expression (resistance) of insulin in HFL associated with insulin resistance
16) Confidence 0.56 Published 2010 Journal Nutr Metab (Lond) Section Body Doc Link PMC2852377 Disease Relevance 0.60 Pain Relevance 0.03
Interestingly, the ability of insulin to repress hepatic glucose production was significantly decreased in HFL and HFPS fed animals compared to HFP fed mice (figure 2).
Gene_expression (production) of insulin in HFL
17) Confidence 0.56 Published 2010 Journal Nutr Metab (Lond) Section Body Doc Link PMC2852377 Disease Relevance 0.22 Pain Relevance 0
In addition to an adverse metabolic phenotype, high dietary stearate levels decreased hepatic insulin sensitivity, characterized by a decreased repression of hepatic glucose production (figure 2) and impaired induction of hepatic PKBser473 phosphorylation by insulin (figure 3A).
Gene_expression (sensitivity) of insulin associated with repression
18) Confidence 0.56 Published 2010 Journal Nutr Metab (Lond) Section Body Doc Link PMC2852377 Disease Relevance 0.55 Pain Relevance 0
In this study, we have addressed the role of stearate in high fat diet induced obesity and insulin resistance.
Gene_expression (resistance) of insulin in fat associated with obesity and insulin resistance
19) Confidence 0.56 Published 2010 Journal Nutr Metab (Lond) Section Body Doc Link PMC2852377 Disease Relevance 0.26 Pain Relevance 0
Thus, high fat diets rich in stearate induce a metabolic state favoring adipogenesis and hepatic insulin resistance.
Gene_expression (resistance) of insulin in fat associated with insulin resistance
20) Confidence 0.56 Published 2010 Journal Nutr Metab (Lond) Section Body Doc Link PMC2852377 Disease Relevance 0.47 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox