INT321303

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Context Info
Confidence 0.42
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 5
Disease Relevance 1.22
Pain Relevance 0.45

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Nr0b2) DNA binding (Nr0b2) protein complex (Nr0b2)
transcription factor binding (Nr0b2) cytoplasm (Nr0b2)
Anatomy Link Frequency
bile 6
Nr0b2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Bile 305 99.20 Very High Very High Very High
agonist 15 5.00 Very Low Very Low Very Low
dexamethasone 10 5.00 Very Low Very Low Very Low
anesthesia 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Fistula 95 99.36 Very High Very High Very High
Repression 20 95.56 Very High Very High Very High
Bordatella Infection 15 83.24 Quite High
Van Bogaert's Disease 15 5.00 Very Low Very Low Very Low
Toxicity 5 5.00 Very Low Very Low Very Low
Vesicular Stomatitis 5 5.00 Very Low Very Low Very Low
Biliary Fistula 5 5.00 Very Low Very Low Very Low
Cytomegalovirus Infection 5 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Activation of the insulin signaling pathway appears to be linked to the upregulation of farnesoid X receptor functional activity and SHP induction.



Positive_regulation (upregulation) of Positive_regulation (induction) of SHP
1) Confidence 0.42 Published 2010 Journal Journal of Lipid Research Section Abstract Doc Link PMC2903791 Disease Relevance 0.26 Pain Relevance 0.07
Because of the time lag between the activation of AKT and induction of SHP mRNA in the chronic bile fistula rat model (Fig. 6), we hypothesized that the activation of the insulin signaling pathway by TCA might be required for maximal activation of FXR and induction of SHP mRNA.
Positive_regulation (required) of Positive_regulation (induction) of SHP in bile associated with bile and fistula
2) Confidence 0.30 Published 2010 Journal Journal of Lipid Research Section Body Doc Link PMC2903791 Disease Relevance 0.23 Pain Relevance 0.11
These results suggest that the insulin signaling pathway must be activated to get optimal induction of SHP mRNA by TCA.
Positive_regulation (activated) of Positive_regulation (induction) of SHP
3) Confidence 0.30 Published 2010 Journal Journal of Lipid Research Section Body Doc Link PMC2903791 Disease Relevance 0.21 Pain Relevance 0.04
Because of the time lag between the activation of AKT and induction of SHP mRNA in the chronic bile fistula rat model (Fig. 6), we hypothesized that the activation of the insulin signaling pathway by TCA might be required for maximal activation of FXR and induction of SHP mRNA.
Positive_regulation (activation) of Positive_regulation (induction) of SHP in bile associated with bile and fistula
4) Confidence 0.30 Published 2010 Journal Journal of Lipid Research Section Body Doc Link PMC2903791 Disease Relevance 0.25 Pain Relevance 0.12
In the chronic bile fistula rat model, we observed a rapid induction of SHP mRNA following the intestinal infusion of TCA (Fig. 6).
Positive_regulation (following) of Positive_regulation (induction) of SHP in bile associated with bile and fistula
5) Confidence 0.28 Published 2010 Journal Journal of Lipid Research Section Body Doc Link PMC2903791 Disease Relevance 0.26 Pain Relevance 0.11

General Comments

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