INT321310

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Context Info
Confidence 0.49
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 11
Disease Relevance 1.75
Pain Relevance 2.75

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Nr1h4) DNA binding (Nr1h4)
Anatomy Link Frequency
bile 5
hepatocytes 1
Nr1h4 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Bile 671 99.56 Very High Very High Very High
agonist 33 61.16 Quite High
anesthesia 11 24.72 Low Low
dexamethasone 22 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Fistula 209 97.46 Very High Very High Very High
Van Bogaert's Disease 33 84.56 Quite High
Bordatella Infection 33 83.24 Quite High
Repression 44 80.88 Quite High
Biliary Fistula 11 32.40 Quite Low
Toxicity 11 5.00 Very Low Very Low Very Low
Vesicular Stomatitis 11 5.00 Very Low Very Low Very Low
Cytomegalovirus Infection 11 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Because of the time lag between the activation of AKT and induction of SHP mRNA in the chronic bile fistula rat model (Fig. 6), we hypothesized that the activation of the insulin signaling pathway by TCA might be required for maximal activation of FXR and induction of SHP mRNA.
Positive_regulation (activation) of FXR in bile associated with bile and fistula
1) Confidence 0.49 Published 2010 Journal Journal of Lipid Research Section Body Doc Link PMC2903791 Disease Relevance 0.23 Pain Relevance 0.11
Bile acids are capable of activating specific nuclear receptors [i.e., farnesoid X receptor (FXR), pregnane X receptor (PXR), Vitamin D], a G?
Positive_regulation (activating) of FXR in Bile associated with bile
2) Confidence 0.49 Published 2010 Journal Journal of Lipid Research Section Body Doc Link PMC2903791 Disease Relevance 0 Pain Relevance 0.39
Activation of the insulin signaling pathway appears to be linked to the upregulation of farnesoid X receptor functional activity and SHP induction.



Positive_regulation (upregulation) of farnesoid X receptor
3) Confidence 0.49 Published 2010 Journal Journal of Lipid Research Section Abstract Doc Link PMC2903791 Disease Relevance 0.26 Pain Relevance 0.07
Bile acids are capable of activating specific nuclear receptors [i.e., farnesoid X receptor (FXR), pregnane X receptor (PXR), Vitamin D], a G?
Positive_regulation (activating) of farnesoid X receptor in Bile associated with bile
4) Confidence 0.49 Published 2010 Journal Journal of Lipid Research Section Body Doc Link PMC2903791 Disease Relevance 0 Pain Relevance 0.39
In addition, activation of FXR downregulates the genes encoding hepatic cholesterol 7?
Positive_regulation (activation) of FXR
5) Confidence 0.33 Published 2010 Journal Journal of Lipid Research Section Body Doc Link PMC2903791 Disease Relevance 0.17 Pain Relevance 0.42
regulates FXR and SHP induction.
Positive_regulation (induction) of FXR
6) Confidence 0.33 Published 2010 Journal Journal of Lipid Research Section Body Doc Link PMC2903791 Disease Relevance 0.17 Pain Relevance 0
Activation of the insulin signaling pathway appears to be linked to the upregulation of farnesoid X receptor functional activity and SHP induction.



Positive_regulation (induction) of farnesoid X receptor
7) Confidence 0.33 Published 2010 Journal Journal of Lipid Research Section Abstract Doc Link PMC2903791 Disease Relevance 0.26 Pain Relevance 0.07
Bile acids have been reported to activate the AKT pathway (insulin signaling pathway) and the nuclear receptor FXR in hepatocytes (18–21, 38–40).
Positive_regulation (activate) of FXR in hepatocytes associated with bile
8) Confidence 0.33 Published 2010 Journal Journal of Lipid Research Section Body Doc Link PMC2903791 Disease Relevance 0.05 Pain Relevance 0.29
Activation of FXR in the liver results in the increased expression of a number of target genes, including the bile salt export pump ABCB11 and the phospholipid transporter ABCB4.
Positive_regulation (Activation) of FXR in bile associated with bile
9) Confidence 0.33 Published 2010 Journal Journal of Lipid Research Section Body Doc Link PMC2903791 Disease Relevance 0.12 Pain Relevance 0.42
We wanted to determine if there is a link between bile acid-activated cell signaling pathways and FXR activation.
Positive_regulation (activation) of FXR in bile associated with bile
10) Confidence 0.33 Published 2010 Journal Journal of Lipid Research Section Body Doc Link PMC2903791 Disease Relevance 0.30 Pain Relevance 0.42
pathway is required for the optimal activation of FXR by taurocholate, which induces the gene encoding the small heterodimeric partner (SHP).
Positive_regulation (activation) of FXR
11) Confidence 0.33 Published 2010 Journal Journal of Lipid Research Section Body Doc Link PMC2903791 Disease Relevance 0.20 Pain Relevance 0.18

General Comments

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