INT321321

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Context Info
Confidence 0.26
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 4
Disease Relevance 0.45
Pain Relevance 0.49

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Nr0b2) DNA binding (Nr0b2) protein complex (Nr0b2)
transcription factor binding (Nr0b2) cytoplasm (Nr0b2)
Anatomy Link Frequency
hepatocytes 2
Nr0b2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
agonist 12 99.52 Very High Very High Very High
Bile 244 97.68 Very High Very High Very High
dexamethasone 8 5.00 Very Low Very Low Very Low
anesthesia 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Fistula 76 88.24 High High
Toxicity 4 35.32 Quite Low
Repression 16 5.00 Very Low Very Low Very Low
Bordatella Infection 12 5.00 Very Low Very Low Very Low
Van Bogaert's Disease 12 5.00 Very Low Very Low Very Low
Vesicular Stomatitis 4 5.00 Very Low Very Low Very Low
Biliary Fistula 4 5.00 Very Low Very Low Very Low
Cytomegalovirus Infection 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Activation of the insulin signaling pathway inhibits induction of SHP by the FXR agonist GW4064
Negative_regulation (inhibits) of Positive_regulation (induction) of SHP associated with agonist
1) Confidence 0.26 Published 2010 Journal Journal of Lipid Research Section Body Doc Link PMC2903791 Disease Relevance 0 Pain Relevance 0.09
The data (Fig. 7A) show that Wortmannin significantly blocked the ability of TCA to induce SHP mRNA in primary hepatocytes in the absence of insulin.
Negative_regulation (blocked) of Positive_regulation (induce) of SHP in hepatocytes
2) Confidence 0.26 Published 2010 Journal Journal of Lipid Research Section Body Doc Link PMC2903791 Disease Relevance 0.14 Pain Relevance 0.07
It has been hypothesized that the downregulation of these genes is through induction of SHP, which has been reported to physically interact with HNF-4?
Negative_regulation (downregulation) of Positive_regulation (induction) of SHP
3) Confidence 0.26 Published 2010 Journal Journal of Lipid Research Section Body Doc Link PMC2903791 Disease Relevance 0.25 Pain Relevance 0.30
Finally, a p38 MAPK and a JNK1/2 inhibitor were also used but failed to inhibit SHP mRNA induction by TCA (data not shown).
Negative_regulation (inhibit) of Positive_regulation (induction) of SHP
4) Confidence 0.26 Published 2010 Journal Journal of Lipid Research Section Body Doc Link PMC2903791 Disease Relevance 0.06 Pain Relevance 0.03

General Comments

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