INT321350

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Context Info
Confidence 0.28
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 4
Disease Relevance 1.04
Pain Relevance 0.91

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lyase activity (Pck1) nucleolus (Pck1) nucleus (Pck1)
lipid metabolic process (Pck1) cytoplasm (Pck1)
Anatomy Link Frequency
hepatocytes 6
Pck1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Bile 244 99.08 Very High Very High Very High
agonist 12 87.88 High High
dexamethasone 8 5.00 Very Low Very Low Very Low
anesthesia 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Fistula 76 98.88 Very High Very High Very High
Bordatella Infection 12 92.80 High High
Toxicity 4 54.80 Quite High
Repression 16 5.00 Very Low Very Low Very Low
Van Bogaert's Disease 12 5.00 Very Low Very Low Very Low
Vesicular Stomatitis 4 5.00 Very Low Very Low Very Low
Biliary Fistula 4 5.00 Very Low Very Low Very Low
Cytomegalovirus Infection 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Downregulation of PEPCK and G-6-Pase mRNA by TCA in the chronic bile fistula rat and primary rat hepatocytes
Negative_regulation (Downregulation) of Transcription (mRNA) of PEPCK in hepatocytes associated with bile and fistula
1) Confidence 0.28 Published 2010 Journal Journal of Lipid Research Section Body Doc Link PMC2903791 Disease Relevance 0.25 Pain Relevance 0.32
50%, 1–2 h) downregulated PEPCK and G-6-Pase mRNA levels in PRH.
Negative_regulation (downregulated) of Transcription (levels) of PEPCK in PRH
2) Confidence 0.28 Published 2010 Journal Journal of Lipid Research Section Abstract Doc Link PMC2903791 Disease Relevance 0.34 Pain Relevance 0.11
50%, 30 min) downregulated mRNA levels of PEPCK and G-6-Pase (Fig. 2).
Negative_regulation (downregulated) of Transcription (levels) of PEPCK
3) Confidence 0.28 Published 2010 Journal Journal of Lipid Research Section Body Doc Link PMC2903791 Disease Relevance 0.24 Pain Relevance 0.27
The addition of TCA alone to primary rat hepatocytes in culture rapidly (1–2 h) downregulated both PEPCK (Fig. 3A) and G-6-Pase mRNA levels (Fig. 3B).
Negative_regulation (downregulated) of Transcription (levels) of PEPCK in hepatocytes
4) Confidence 0.28 Published 2010 Journal Journal of Lipid Research Section Body Doc Link PMC2903791 Disease Relevance 0.21 Pain Relevance 0.21

General Comments

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