INT321350

Context Info Confidence 0.28 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 4 Disease Relevance 1.04 Pain Relevance 0.91

lyase activity (Pck1) nucleolus (Pck1) nucleus (Pck1) lipid metabolic process (Pck1) cytoplasm (Pck1)

Anatomy Link Frequency hepatocytes 6 Pck1 (Rattus norvegicus)

Pain Link Frequency Relevance Heat Bile 244 99.08 agonist 12 87.88 dexamethasone 8 5.00 anesthesia 4 5.00

Disease Link Frequency Relevance Heat Fistula 76 98.88 Bordatella Infection 12 92.80 Toxicity 4 54.80 Repression 16 5.00 Van Bogaert's Disease 12 5.00 Vesicular Stomatitis 4 5.00 Biliary Fistula 4 5.00 Cytomegalovirus Infection 4 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Downregulation of PEPCK and G-6-Pase mRNA by TCA in the chronic bile fistula rat and primary rat hepatocytes

Negative_regulation (Downregulation) of Transcription (mRNA) of PEPCK in hepatocytes associated with bile and fistula

1) Confidence 0.28 Published 2010 Journal Journal of Lipid Research Section Body Doc Link PMC2903791 Disease Relevance 0.25 Pain Relevance 0.32

50%, 1–2 h) downregulated PEPCK and G-6-Pase mRNA levels in PRH.

Negative_regulation (downregulated) of Transcription (levels) of PEPCK in PRH

2) Confidence 0.28 Published 2010 Journal Journal of Lipid Research Section Abstract Doc Link PMC2903791 Disease Relevance 0.34 Pain Relevance 0.11

50%, 30 min) downregulated mRNA levels of PEPCK and G-6-Pase (Fig. 2).

Negative_regulation (downregulated) of Transcription (levels) of PEPCK

3) Confidence 0.28 Published 2010 Journal Journal of Lipid Research Section Body Doc Link PMC2903791 Disease Relevance 0.24 Pain Relevance 0.27

The addition of TCA alone to primary rat hepatocytes in culture rapidly (1–2 h) downregulated both PEPCK (Fig. 3A) and G-6-Pase mRNA levels (Fig. 3B).

Negative_regulation (downregulated) of Transcription (levels) of PEPCK in hepatocytes

4) Confidence 0.28 Published 2010 Journal Journal of Lipid Research Section Body Doc Link PMC2903791 Disease Relevance 0.21 Pain Relevance 0.21

General Comments

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