INT32137

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Context Info
Confidence 0.36
First Reported 1985
Last Reported 2010
Negated 2
Speculated 0
Reported most in Body
Documents 7
Total Number 7
Disease Relevance 2.17
Pain Relevance 0.49

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Ca2) extracellular space (Ca2) lyase activity (Ca2)
response to stress (Ca2) cytoplasm (Ca2)
Anatomy Link Frequency
plasma 2
Ca2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
qutenza 72 88.16 High High
Paracetamol 3 81.68 Quite High
antagonist 16 77.92 Quite High
Glutamate 3 67.20 Quite High
agonist 23 50.00 Quite Low
adenocard 25 27.44 Quite Low
Action potential 14 26.20 Quite Low
Central nervous system 5 14.32 Low Low
ASIC 18 5.00 Very Low Very Low Very Low
Inflammation 13 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Acidosis 141 98.20 Very High Very High Very High
Repression 1 97.28 Very High Very High Very High
Apoptosis 28 96.52 Very High Very High Very High
Retinal Degeneration 29 96.12 Very High Very High Very High
Injury 16 95.56 Very High Very High Very High
Hypoxia 114 94.72 High High
Death 8 84.00 Quite High
Blister 1 79.52 Quite High
Stress 11 78.32 Quite High
Toxicity 1 75.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The speed of rise and average Ca2+ amplitude were generally unaffected by removal of Ca2+, with the exception of a slight decrease of the Ca2+ concentration reached when ATP was used (data not shown).
Neg (unaffected) Regulation (unaffected) of Negative_regulation (decrease) of Ca2
1) Confidence 0.36 Published 2006 Journal Purinergic Signal Section Body Doc Link PMC2096653 Disease Relevance 0.07 Pain Relevance 0
The speed of rise and average Ca2+ amplitude were generally unaffected by removal of Ca2+, with the exception of a slight decrease of the Ca2+ concentration reached when ATP was used (data not shown).
Neg (unaffected) Regulation (unaffected) of Negative_regulation (removal) of Ca2
2) Confidence 0.36 Published 2006 Journal Purinergic Signal Section Body Doc Link PMC2096653 Disease Relevance 0.06 Pain Relevance 0
Our results also demonstrated that inhibition of Ca2+ overload is modulated by proteins involved in Ca2+ homeostasis.
Regulation (modulated) of Negative_regulation (inhibition) of Ca2
3) Confidence 0.26 Published 2010 Journal Yonsei Medical Journal Section Body Doc Link PMC2824862 Disease Relevance 0.67 Pain Relevance 0.03
This loss of protein thiols may have been responsible for the observed inhibition of the high-affinity Ca2+-ATPase activity of the plasma membrane fraction isolated from NAPQI-treated cells.
Regulation (responsible) of Negative_regulation (inhibition) of Ca2 in plasma
4) Confidence 0.25 Published 1985 Journal J. Biol. Chem. Section Abstract Doc Link 2932433 Disease Relevance 0.24 Pain Relevance 0.22
The effects of removal of extracellular Ca2+ on the acid-evoked Ca2+ response are included for comparison.
Regulation (effects) of Negative_regulation (removal) of Ca2
5) Confidence 0.22 Published 2009 Journal Pflugers Arch Section Body Doc Link PMC2765625 Disease Relevance 0.51 Pain Relevance 0.17
Recently, to clarify this ambiguity regarding the effect of Ca2+ channel blocker, we systematically studied the effects of several kinds of Ca2+ channel blockers, including D-cis-diltiazem, nicardipine, nilvadipine and nifedipine against several models with retinal degeneration.
Regulation (effects) of Negative_regulation (blockers) of Ca2 associated with retinal degeneration
6) Confidence 0.20 Published 2008 Journal Clinical Ophthalmology (Auckland, N.Z.) Section Body Doc Link PMC2699806 Disease Relevance 0.62 Pain Relevance 0
Ca2+-dependent Ca2+ channel inactivation can also contribute to the repolarization by decreasing the inward Ca2+ current and this also helps to lower the intracellular Ca2+ concentrations back to resting levels.
Regulation (dependent) of Negative_regulation (inactivation) of Ca2
7) Confidence 0.17 Published 2005 Journal Purinergic Signal Section Body Doc Link PMC2096533 Disease Relevance 0 Pain Relevance 0.08

General Comments

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