INT32138

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Context Info
Confidence 0.02
First Reported 1985
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 0.86
Pain Relevance 0.33

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Neu2) hydrolase activity, acting on glycosyl bonds (Neu2) cytoplasm (Neu2)
Anatomy Link Frequency
plasma 1
Neu2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Paracetamol 6 97.44 Very High Very High Very High
ischemia 16 5.00 Very Low Very Low Very Low
qutenza 8 5.00 Very Low Very Low Very Low
Calcitonin gene-related peptide 5 5.00 Very Low Very Low Very Low
substance P 3 5.00 Very Low Very Low Very Low
ASIC 2 5.00 Very Low Very Low Very Low
tissue acidosis 1 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
halothane 1 5.00 Very Low Very Low Very Low
antagonist 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Blister 2 95.36 Very High Very High Very High
Hypoxia 146 94.24 High High
Death 2 81.76 Quite High
Toxicity 2 75.00 Quite High
Cv Unclassified Under Development 14 5.00 Very Low Very Low Very Low
Acidosis 3 5.00 Very Low Very Low Very Low
Alkalosis 2 5.00 Very Low Very Low Very Low
Coronary Artery Disease 2 5.00 Very Low Very Low Very Low
Nociception 2 5.00 Very Low Very Low Very Low
Increased Venous Pressure Under Development 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In addition, NAPQI inhibited microsomal Ca2+ uptake which would further contribute to the elevation in cytosolic Ca2+.
Positive_regulation (elevation) of cytosolic
1) Confidence 0.02 Published 1985 Journal J. Biol. Chem. Section Abstract Doc Link 2932433 Disease Relevance 0.22 Pain Relevance 0.17
Both agents caused an elevation of cytosolic Ca2+, assessed by phosphorylase a activity, which was accompanied by the concomitant appearance of plasma membrane blebs.
Positive_regulation (elevation) of cytosolic in plasma associated with blister
2) Confidence 0.02 Published 1985 Journal J. Biol. Chem. Section Abstract Doc Link 2932433 Disease Relevance 0.25 Pain Relevance 0.16
The current concept of the role of mitochondria in cellular Ca2+ homeostasis is that under conditions in which cytosolic [Ca2+]i is substantially elevated, the mitochondrion avidly takes up Ca2+ via the uniporter driven by both the calcium gradient and the mitochondrial transmembrane potential (?
Positive_regulation (elevated) of cytosolic
3) Confidence 0.00 Published 2008 Journal Journal of Neurophysiology Section Body Doc Link PMC2493471 Disease Relevance 0.38 Pain Relevance 0

General Comments

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