INT321399

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Context Info
Confidence 0.00
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 1.25
Pain Relevance 0.06

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

methyltransferase activity (SETD7, SETDB1) chromosome (SETD7, SETDB1) nucleus (SETD7, SETDB1)
Golgi apparatus (SETDB1) DNA binding (SETDB1) cytoplasm (SETDB1)
Anatomy Link Frequency
proximal 4
SETD7 (Homo sapiens)
SETDB1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Kinase C 20 65.16 Quite High
Inflammation 58 50.00 Quite Low
cytokine 26 5.00 Very Low Very Low Very Low
bradykinin 6 5.00 Very Low Very Low Very Low
spinal inflammation 4 5.00 Very Low Very Low Very Low
COX2 2 5.00 Very Low Very Low Very Low
COX-2 inhibitor 2 5.00 Very Low Very Low Very Low
Inflammatory response 2 5.00 Very Low Very Low Very Low
Bioavailability 2 5.00 Very Low Very Low Very Low
Etanercept 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hyperglycemia 76 95.16 Very High Very High Very High
Apoptosis 178 78.56 Quite High
Injury 10 77.96 Quite High
Stress 62 77.28 Quite High
Diabetes Complications 6 51.68 Quite High
INFLAMMATION 58 50.00 Quite Low
Diabetes Mellitus 166 48.20 Quite Low
Aging 22 43.44 Quite Low
Insulin Resistance 54 5.00 Very Low Very Low Very Low
Increased Venous Pressure Under Development 38 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In the proximal promoter region of p65, increased monomethylation of histone 3 lysine 4 by the histone methyltransferase Set 7 caused a continuing increase in p65 gene expression, leading to a sustained increase in the expression of the NF-?
Positive_regulation (increased) of methyltransferase Set 7 Positive_regulation (monomethylation) of histone 3 lysine 4 in proximal
1) Confidence 0.00 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2903979 Disease Relevance 0.63 Pain Relevance 0.03
In the proximal promoter region of p65, increased monomethylation of histone 3 lysine 4 by the histone methyltransferase Set 7 caused a continuing increase in p65 gene expression, leading to a sustained increase in the expression of the NF-?
Positive_regulation (caused) of methyltransferase Set 7 Positive_regulation (monomethylation) of histone 3 lysine 4 in proximal
2) Confidence 0.00 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2903979 Disease Relevance 0.63 Pain Relevance 0.03

General Comments

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