INT3214

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Context Info
Confidence 0.80
First Reported 1978
Last Reported 2011
Negated 2
Speculated 2
Reported most in Abstract
Documents 527
Total Number 542
Disease Relevance 196.90
Pain Relevance 79.26

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Ins1) extracellular region (Ins1) carbohydrate metabolic process (Ins1)
cytoplasm (Ins1)
Anatomy Link Frequency
plasma 23
blood 18
pancreatic islets 17
beta cells 11
sympathetic 9
Ins1 (Mus musculus)
Pain Link Frequency Relevance Heat
tolerance 2457 100.00 Very High Very High Very High
Inflammation 1038 100.00 Very High Very High Very High
cytokine 424 100.00 Very High Very High Very High
chemokine 162 100.00 Very High Very High Very High
qutenza 105 100.00 Very High Very High Very High
Endogenous opioid 11 100.00 Very High Very High Very High
calcitonin gene related peptide 5 100.00 Very High Very High Very High
agonist 1670 99.96 Very High Very High Very High
antagonist 1311 99.92 Very High Very High Very High
Somatostatin 477 99.92 Very High Very High Very High
Disease Link Frequency Relevance Heat
Insulin Resistance 2958 100.00 Very High Very High Very High
Impaired Glucose Tolerance 2335 100.00 Very High Very High Very High
Hyperinsulinism 1461 100.00 Very High Very High Very High
INFLAMMATION 1193 100.00 Very High Very High Very High
Hyperglycemia 1560 99.92 Very High Very High Very High
Hypoglycemia 1332 99.92 Very High Very High Very High
Stress 843 99.92 Very High Very High Very High
Persistent Hyperinsulinemia Hypoglycemia Of Infancy 10 99.92 Very High Very High Very High
Obesity 6469 99.90 Very High Very High Very High
Osteoporosis 318 99.80 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Insulin release in response to glucose was measured after culture of islets from ob/ob-mice in a Ca2+-deficient medium.
Localization (release) of Insulin
1) Confidence 0.80 Published 1986 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 2876704 Disease Relevance 0 Pain Relevance 0.14
Unmasking of the inhibitory action of glucose on insulin release after alpha 2-adrenergic activation.
Localization (release) of insulin
2) Confidence 0.80 Published 1986 Journal Biochem. Biophys. Res. Commun. Section Title Doc Link 2876704 Disease Relevance 0 Pain Relevance 0.17
It is concluded that alpha 2-adrenergic activation provides an efficient means of unmasking the inhibitory component in the action of glucose on insulin release.
Localization (release) of insulin
3) Confidence 0.80 Published 1986 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 2876704 Disease Relevance 0 Pain Relevance 0.18
Glucose inhibited insulin release also after activation of the alpha 2-adrenoceptors with B-HT 933, whereas blocking of these receptors with idazoxan removed glucose inhibition in the presence of clonidine.
Localization (release) of insulin associated with clonidine
4) Confidence 0.80 Published 1986 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 2876704 Disease Relevance 0 Pain Relevance 0.19
In an attempt to find differences between these mutations in neuroendocrine function affecting the islets of Langerhans or the pituitary, tissue content of four neuropeptides that are known to be capable of influencing the rate of insulin secretion was examined in obese (ob/ob) and diabetes (db/db) mice.
Localization (secretion) of insulin in pituitary associated with diabetes mellitus, obesity and neuropeptide
5) Confidence 0.80 Published 1990 Journal Metab. Clin. Exp. Section Abstract Doc Link 1691431 Disease Relevance 1.14 Pain Relevance 0.09
It is concluded that activation of alpha 2-adrenoceptors has profound effects on the sodium handling of pancreatic beta-cells exposed to glucose and other stimulators of insulin release.
Localization (release) of insulin
6) Confidence 0.80 Published 1995 Journal Acta Diabetol Section Abstract Doc Link 7579539 Disease Relevance 0 Pain Relevance 0.39
In the presence of 15 mM glucose, SL 84.0418 produced a concentration-dependent (0.1-100 microM) increase of insulin release with a slightly higher potency than tolbutamide.
Localization (release) of insulin associated with potency
7) Confidence 0.80 Published 1994 Journal Eur. J. Pharmacol. Section Abstract Doc Link 7911430 Disease Relevance 0.05 Pain Relevance 0.40
When alpha 2-adrenoceptors were blocked by the antagonist idazoxan, the low concentrations of SL 84.0418 (0.1-0.3 microM) no longer increased insulin release, whereas the effect of higher concentrations (> or = 1 microM) was not affected.
Localization (release) of insulin associated with antagonist and hyperinsulinism
8) Confidence 0.80 Published 1994 Journal Eur. J. Pharmacol. Section Abstract Doc Link 7911430 Disease Relevance 0.10 Pain Relevance 0.42
In vitro stimulation of insulin release by SL 84.0418, a new alpha 2-adrenoceptor antagonist.
Localization (release) of insulin associated with antagonist
9) Confidence 0.80 Published 1994 Journal Eur. J. Pharmacol. Section Title Doc Link 7911430 Disease Relevance 0.06 Pain Relevance 0.38
SL 84.0418 antagonized the inhibition of glucose-induced insulin release caused either by the alpha 2-adrenoceptor agonist clonidine or by diazoxide, a selective opener of ATP-sensitive K+ channels in the beta-cell membrane.
Localization (release) of insulin associated with agonist and clonidine
10) Confidence 0.80 Published 1994 Journal Eur. J. Pharmacol. Section Abstract Doc Link 7911430 Disease Relevance 0.06 Pain Relevance 0.44
Other test substances also affected sodium uptake in a way reflecting known effects on insulin release.
Localization (release) of insulin
11) Confidence 0.80 Published 1994 Journal Eur. J. Pharmacol. Section Abstract Doc Link 7925593 Disease Relevance 0.08 Pain Relevance 0.07
SL 84.0418 (2-(4,5-dihydro-1H-imidazol-2-yl)-1,2,4,5-tetrahydro-2-propyl-pyrrolo[3, 2,1- hi]-indole hydrocholoride) is a novel alpha 2-adrenoceptor antagonist which possesses anti-hyperglycaemic properties in vitro study, we tested its effects on insulin release from isolated mouse islets.
Localization (release) of insulin associated with antagonist
12) Confidence 0.80 Published 1994 Journal Eur. J. Pharmacol. Section Abstract Doc Link 7911430 Disease Relevance 0 Pain Relevance 0.34
It was recently reported to inhibit alpha 2-adrenoceptors and ATP-sensitive K+ channels in mouse pancreatic B-cells, and to increase insulin release.
Localization (release) of insulin in B-cells
13) Confidence 0.80 Published 1994 Journal Eur. J. Pharmacol. Section Abstract Doc Link 7828647 Disease Relevance 0 Pain Relevance 0.04
Both enantiomers were equipotent in potentiating insulin release induced by 15 mM glucose alone.
Localization (release) of insulin
14) Confidence 0.80 Published 1994 Journal Eur. J. Pharmacol. Section Abstract Doc Link 7828647 Disease Relevance 0 Pain Relevance 0.10
SL 86.0714 and deriglidole were also equally effective in inhibiting 86Rb efflux from islets perifused with a low-glucose medium, and in reversing the inhibition of glucose-induced insulin release caused by the opening of ATP-sensitive K+ channels with diazoxide.
Localization (release) of insulin
15) Confidence 0.80 Published 1994 Journal Eur. J. Pharmacol. Section Abstract Doc Link 7828647 Disease Relevance 0 Pain Relevance 0.12
In contrast, deriglidole was approximately 100-fold more potent than SL 86.0714 in reversing the inhibition of insulin release caused by the activation of alpha 2-adrenoceptors with clonidine.
Localization (release) of insulin associated with clonidine
16) Confidence 0.80 Published 1994 Journal Eur. J. Pharmacol. Section Abstract Doc Link 7828647 Disease Relevance 0 Pain Relevance 0.13
The observed differences in glucose metabolism between normal and transplanted mice may be attributed to the site of transplantation and to the use of rat islets, which have a different set point for glucose induced insulin release.


Localization (release) of insulin
17) Confidence 0.80 Published 1999 Journal Transplantation Section Body Doc Link 10096520 Disease Relevance 0 Pain Relevance 0
The effects of two kappa-opiate agonists, U 50488h and dynorphin A1-13, on plasma insulin and glucose concentrations in vivo and insulin release in vitro were tested in fasted genetically obese (ob/ob) and lean (+/+) mice at 12-15 wk of age.
Localization (release) of insulin in plasma associated with dynorphin, obesity, agonist and opiate
18) Confidence 0.80 Published 1990 Journal Diabetes Section Abstract Doc Link 1976559 Disease Relevance 0.17 Pain Relevance 0.26
It has been established that insulin secretion is regulated by autonomic nervous homeostasis.
Localization (secretion) of insulin in autonomic
19) Confidence 0.79 Published 2010 Journal Neurosci. Lett. Section Abstract Doc Link 20471451 Disease Relevance 0 Pain Relevance 0.07
Blockade of muscarinic receptors by atropine inhibited ginseng-induced insulin secretion in anesthetized mice.
Localization (secretion) of insulin
20) Confidence 0.79 Published 2010 Journal Neurosci. Lett. Section Abstract Doc Link 20471451 Disease Relevance 0.09 Pain Relevance 0.12

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