INT321401

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Context Info
Confidence 0.01
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.80
Pain Relevance 0.05

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (ROS1) small molecule metabolic process (AKR1B1) carbohydrate metabolic process (AKR1B1)
response to stress (AKR1B1) cytoplasm (AKR1B1) cell proliferation (ROS1)
ROS1 (Homo sapiens)
AKR1B1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Kinase C 10 99.08 Very High Very High Very High
Inflammation 29 50.00 Quite Low
cytokine 13 5.00 Very Low Very Low Very Low
bradykinin 3 5.00 Very Low Very Low Very Low
spinal inflammation 2 5.00 Very Low Very Low Very Low
COX2 1 5.00 Very Low Very Low Very Low
COX-2 inhibitor 1 5.00 Very Low Very Low Very Low
Inflammatory response 1 5.00 Very Low Very Low Very Low
Bioavailability 1 5.00 Very Low Very Low Very Low
Etanercept 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hyperglycemia 38 99.78 Very High Very High Very High
Stress 31 98.08 Very High Very High Very High
Diabetes Mellitus 83 86.40 High High
Injury 5 72.80 Quite High
Apoptosis 89 71.84 Quite High
INFLAMMATION 29 50.00 Quite Low
Coronary Artery Disease 1 27.44 Quite Low
Increased Venous Pressure Under Development 19 26.36 Quite Low
Insulin Resistance 27 5.00 Very Low Very Low Very Low
Adhesions 16 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Oxidative stress is probably a key event in endothelial dysfunction since inhibition of hyperglycemia, induced, ROS production prevents activation of the aldose reductase, hexosamine pathways, PKC activation, and AGE formation [77, 89].
Gene_expression (production) of ROS Negative_regulation (prevents) of Positive_regulation (activation) of aldose reductase associated with hyperglycemia, stress and kinase c
1) Confidence 0.01 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2903979 Disease Relevance 0.80 Pain Relevance 0.05

General Comments

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