INT321404

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Context Info
Confidence 0.02
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 2.20
Pain Relevance 0.12

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (SERPINE1) extracellular region (SERPINE1) endoplasmic reticulum (MAP3K5)
plasma membrane (SERPINE1) response to stress (MAP3K5) cytoplasm (MAP3K5)
Anatomy Link Frequency
aortas 3
MAP3K5 (Homo sapiens)
SERPINE1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 29 85.52 High High
cytokine 13 77.20 Quite High
Kinase C 10 5.00 Very Low Very Low Very Low
bradykinin 3 5.00 Very Low Very Low Very Low
spinal inflammation 2 5.00 Very Low Very Low Very Low
COX2 1 5.00 Very Low Very Low Very Low
COX-2 inhibitor 1 5.00 Very Low Very Low Very Low
Inflammatory response 1 5.00 Very Low Very Low Very Low
Bioavailability 1 5.00 Very Low Very Low Very Low
Etanercept 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Aging 11 98.84 Very High Very High Very High
Apoptosis 89 98.56 Very High Very High Very High
Diabetes Mellitus 83 97.00 Very High Very High Very High
Targeted Disruption 1 94.08 High High
Thrombosis 5 86.12 High High
Vasculitis 4 85.52 High High
Increased Venous Pressure Under Development 19 81.76 Quite High
Hyperglycemia 38 78.40 Quite High
Adhesions 16 77.72 Quite High
INFLAMMATION 29 76.80 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Activation of ASK-1 also upregulated PAI-1 expression in the HUVECs and this plus senescence was also observed in aortas of STZ-diabetic wild type mice, whereas this was not seen in STZ-diabetic ASK-1 knock-out mice.
Positive_regulation (Activation) of ASK-1 in aortas Positive_regulation (upregulated) of Gene_expression (expression) of PAI-1 in aortas associated with targeted disruption, aging and diabetes mellitus
1) Confidence 0.02 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2903979 Disease Relevance 2.20 Pain Relevance 0.12

General Comments

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