INT321405

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Context Info
Confidence 0.00
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.94
Pain Relevance 0.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (MAPK8) mitochondrion (MAPK8) small molecule metabolic process (AGT)
aging (AGT) extracellular matrix organization (AGT) response to stress (MAPK8)
Anatomy Link Frequency
endothelial cells 1
AGT (Homo sapiens)
MAPK8 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 29 59.08 Quite High
cytokine 13 32.96 Quite Low
rheumatoid arthritis 1 12.96 Low Low
spinal inflammation 2 8.56 Low Low
Kinase C 10 5.00 Very Low Very Low Very Low
bradykinin 3 5.00 Very Low Very Low Very Low
COX2 1 5.00 Very Low Very Low Very Low
COX-2 inhibitor 1 5.00 Very Low Very Low Very Low
Inflammatory response 1 5.00 Very Low Very Low Very Low
Bioavailability 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 89 92.88 High High
Obesity 8 88.80 High High
Thrombosis 5 85.44 High High
Metabolic Syndrome 15 82.96 Quite High
Diabetes Mellitus 83 71.76 Quite High
Insulin Resistance 27 70.68 Quite High
Adhesions 16 68.16 Quite High
INFLAMMATION 29 59.08 Quite High
Stress 31 58.24 Quite High
Hyperglycemia 38 45.84 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Angiotensin also activates JNK and MAPK pathways in endothelial cells, which leads to increased serine phosphorylation of IRS-1, impaired PI-3 kinase activity and finally endothelial dysfunction and probably apoptosis.
Angiotensin Positive_regulation (activates) of JNK in endothelial cells associated with apoptosis
1) Confidence 0.00 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2903979 Disease Relevance 0.94 Pain Relevance 0.03

General Comments

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