INT321407

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Context Info
Confidence 0.06
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 1.07
Pain Relevance 0.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (EDN1, IRS1) signal transducer activity (IRS1) cell-cell signaling (EDN1)
cytosol (IRS1) signal transduction (IRS1) extracellular space (EDN1)
Anatomy Link Frequency
smooth muscle cells 2
EDN1 (Homo sapiens)
IRS1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 29 53.96 Quite High
cytokine 13 29.04 Quite Low
Kinase C 10 5.00 Very Low Very Low Very Low
bradykinin 3 5.00 Very Low Very Low Very Low
spinal inflammation 2 5.00 Very Low Very Low Very Low
COX2 1 5.00 Very Low Very Low Very Low
COX-2 inhibitor 1 5.00 Very Low Very Low Very Low
Inflammatory response 1 5.00 Very Low Very Low Very Low
Bioavailability 1 5.00 Very Low Very Low Very Low
Etanercept 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hyperinsulinism 8 95.64 Very High Very High Very High
Obesity 8 87.52 High High
Hypertension 10 85.28 High High
Insulin Resistance 27 75.44 Quite High
Adhesions 16 72.64 Quite High
Diabetes Mellitus 83 71.76 Quite High
INFLAMMATION 29 53.96 Quite High
Stress 31 53.28 Quite High
Apoptosis 89 50.00 Quite Low
Vasculitis 4 44.48 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
ET-1, a vasoconstrictor, can increase serine phosphorylation of IRS-1, causing a decreased activity of PI-3 kinase in vascular smooth muscle cells.
ET-1 Positive_regulation (increase) of Phosphorylation (phosphorylation) of IRS-1 in smooth muscle cells
1) Confidence 0.06 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2903979 Disease Relevance 1.07 Pain Relevance 0.03

General Comments

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