INT321408

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Context Info
Confidence 0.03
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 2.36
Pain Relevance 0.13

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (EGR1) small molecule metabolic process (INS) intracellular (EGR1)
DNA binding (EGR1) carbohydrate metabolic process (INS) cytoplasm (EGR1)
Anatomy Link Frequency
endothelial cells 2
INS (Homo sapiens)
EGR1 (Homo sapiens)
Pain Link Frequency Relevance Heat
cva 2 69.96 Quite High
Inflammation 58 57.28 Quite High
cytokine 26 37.28 Quite Low
Kinase C 20 5.00 Very Low Very Low Very Low
bradykinin 6 5.00 Very Low Very Low Very Low
spinal inflammation 4 5.00 Very Low Very Low Very Low
COX2 2 5.00 Very Low Very Low Very Low
COX-2 inhibitor 2 5.00 Very Low Very Low Very Low
Inflammatory response 2 5.00 Very Low Very Low Very Low
Bioavailability 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hyperglycemia 76 100.00 Very High Very High Very High
Diabetes Mellitus 166 97.48 Very High Very High Very High
Increased Venous Pressure Under Development 38 80.32 Quite High
Cv General 3 Under Development 2 69.96 Quite High
Cardiovascular Disease 16 68.80 Quite High
Atherosclerosis 4 64.24 Quite High
INFLAMMATION 58 57.28 Quite High
Toxicity 2 56.60 Quite High
Apoptosis 178 52.96 Quite High
Death 28 51.52 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
A possible explanation for these results is the upregulation of the transcription factor early growth response protein 1 (Egr-1), which in turn downregulates TRAIL expression in endothelial cells, by both hyperglycemia and insulin.
insulin Positive_regulation (upregulation) of Egr-1 in endothelial cells associated with hyperglycemia
1) Confidence 0.03 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2903979 Disease Relevance 1.18 Pain Relevance 0.06
A possible explanation for these results is the upregulation of the transcription factor early growth response protein 1 (Egr-1), which in turn downregulates TRAIL expression in endothelial cells, by both hyperglycemia and insulin.
insulin Positive_regulation (upregulation) of factor early growth response protein 1 in endothelial cells associated with hyperglycemia
2) Confidence 0.03 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2903979 Disease Relevance 1.18 Pain Relevance 0.06

General Comments

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