INT321429

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Context Info
Confidence 0.03
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 1.78
Pain Relevance 0.41

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (PTPN6) cell proliferation (PTPN6) cytosol (PTPN6)
nucleus (PTPN6) cytoplasm (PTPN6)
Anatomy Link Frequency
platelet 4
PTPN6 (Homo sapiens)
Pain Link Frequency Relevance Heat
Kinase C 20 98.24 Very High Very High Very High
Inflammation 58 50.00 Quite Low
cytokine 26 5.00 Very Low Very Low Very Low
bradykinin 6 5.00 Very Low Very Low Very Low
spinal inflammation 4 5.00 Very Low Very Low Very Low
COX2 2 5.00 Very Low Very Low Very Low
COX-2 inhibitor 2 5.00 Very Low Very Low Very Low
Inflammatory response 2 5.00 Very Low Very Low Very Low
Bioavailability 2 5.00 Very Low Very Low Very Low
Etanercept 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 178 98.80 Very High Very High Very High
Hyperglycemia 76 93.68 High High
Diabetic Retinopathy 6 91.72 High High
Stress 62 84.36 Quite High
Diabetes Mellitus 166 77.28 Quite High
Renal Failure 6 76.24 Quite High
INFLAMMATION 58 50.00 Quite Low
Diabetes Complications 6 14.48 Low Low
Insulin Resistance 54 5.00 Very Low Very Low Very Low
Increased Venous Pressure Under Development 38 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
MAPK leads to increased expression of Scr homology-2 domain-containing phosphatase-1 (SHP-1), which subsequently induces apoptosis via deactivation of platelet-derived growth factor ?
Positive_regulation (increased) of Gene_expression (expression) of SHP-1 in platelet associated with apoptosis
1) Confidence 0.03 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2903979 Disease Relevance 0.89 Pain Relevance 0.20
MAPK leads to increased expression of Scr homology-2 domain-containing phosphatase-1 (SHP-1), which subsequently induces apoptosis via deactivation of platelet-derived growth factor ?
Positive_regulation (leads) of Gene_expression (expression) of SHP-1 in platelet associated with apoptosis
2) Confidence 0.03 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2903979 Disease Relevance 0.89 Pain Relevance 0.20

General Comments

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