INT32145

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Context Info
Confidence 0.73
First Reported 1982
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 7
Total Number 7
Disease Relevance 3.20
Pain Relevance 1.70

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Reg1)
Anatomy Link Frequency
vesicles 2
PSP 2
pancreatic islet 1
acinar cells 1
synapse 1
Reg1 (Mus musculus)
Pain Link Frequency Relevance Heat
Enkephalin 4 99.60 Very High Very High Very High
Bile 11 96.80 Very High Very High Very High
Neurotransmitter 2 94.96 High High
Chronic pancreatitis 9 94.08 High High
medulla 2 93.88 High High
adenocard 1 88.28 High High
noradrenaline 1 87.76 High High
narcan 3 85.84 High High
wide dynamic range 1 79.92 Quite High
alcohol 3 79.60 Quite High
Disease Link Frequency Relevance Heat
Alzheimer's Dementia 4 97.82 Very High Very High Very High
Cancer 98 97.76 Very High Very High Very High
Pancreatitis 22 96.76 Very High Very High Very High
Anaerobic Bacterial Infections 3 96.76 Very High Very High Very High
Calculi 2 91.88 High High
Lithiasis 1 91.40 High High
Pancreatic Cancer 59 90.84 High High
Disease 16 87.44 High High
Adhesions 3 84.80 Quite High
Choledochal Cyst 2 82.56 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The hypothesis of a presynaptic origin of PTP at this muscarinic synapse was corroborated in the experiments where acetylcholine stores were labelled with [3H] choline and the release of the label was increased during PTP.
Localization (release) of PTP in synapse
1) Confidence 0.73 Published 1982 Journal Eur. J. Pharmacol. Section Abstract Doc Link 7094998 Disease Relevance 0.23 Pain Relevance 0.27
This has now been identified as a 13500 daltons molecular weight protein: the pancreatic stone protein secreted by the acinar cells.
Localization (secreted) of pancreatic stone protein in acinar cells
2) Confidence 0.60 Published 1985 Journal Presse Med Section Abstract Doc Link 2933679 Disease Relevance 0.74 Pain Relevance 0.12
The formation of precipitates depends on two mechanisms: (1) a non etiological disorder reducing the secretion of PSP.
Localization (secretion) of PSP in PSP
3) Confidence 0.59 Published 1987 Journal Reprod Nutr Dev Section Abstract Doc Link 3303203 Disease Relevance 0.69 Pain Relevance 0.21
Activity of pancreatic enzymes and the concentration of PSP were measured.
Localization (concentration) of PSP in PSP
4) Confidence 0.16 Published 2004 Journal Dig. Dis. Sci. Section Abstract Doc Link 15628732 Disease Relevance 0.25 Pain Relevance 0.56
In chromaffin cells, calcium-dependent secretion of KPI/APP with PTP and (Met)enkephalin demonstrated the colocalization of these components in functional secretory vesicles.
Localization (secretion) of PTP in vesicles associated with enkephalin
5) Confidence 0.06 Published 1999 Journal J. Biol. Chem. Section Abstract Doc Link 9915856 Disease Relevance 0.15 Pain Relevance 0.27
Colocalization of KPI/APP and PTP in secretory vesicles.
Localization (Colocalization) of PTP in vesicles
6) Confidence 0.05 Published 1999 Journal J. Biol. Chem. Section Title Doc Link 9915856 Disease Relevance 0.18 Pain Relevance 0.20
REG1A and REG3 are proteins highly secreted by pancreatic islet cells and have also been described as potential markers for pancreatic diseases [38].
Localization (secreted) of REG1A in pancreatic islet associated with pancreatitis
7) Confidence 0.02 Published 2008 Journal PLoS Medicine Section Body Doc Link PMC2504036 Disease Relevance 0.96 Pain Relevance 0.08

General Comments

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