INT3215

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Context Info
Confidence 0.52
First Reported 1978
Last Reported 2011
Negated 7
Speculated 3
Reported most in Body
Documents 32
Total Number 35
Disease Relevance 19.83
Pain Relevance 4.85

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Ins1) extracellular region (Ins1) carbohydrate metabolic process (Ins1)
cytoplasm (Ins1)
Anatomy Link Frequency
plasma 11
fat 5
skeletal muscle 4
beta cells 4
myeloid cell 3
Ins1 (Mus musculus)
Pain Link Frequency Relevance Heat
tolerance 167 100.00 Very High Very High Very High
agonist 87 100.00 Very High Very High Very High
antagonist 57 100.00 Very High Very High Very High
Clonidine 22 100.00 Very High Very High Very High
opioid receptor 1 99.68 Very High Very High Very High
Intracerebroventricular 19 99.44 Very High Very High Very High
Antinociceptive 12 99.36 Very High Very High Very High
Kinase C 53 99.34 Very High Very High Very High
Morphine 11 98.84 Very High Very High Very High
Inflammation 229 98.48 Very High Very High Very High
Disease Link Frequency Relevance Heat
Insulin Resistance 493 100.00 Very High Very High Very High
Impaired Glucose Tolerance 156 100.00 Very High Very High Very High
Acromegaly 36 100.00 Very High Very High Very High
Metabolic Disorder 35 100.00 Very High Very High Very High
Obesity 1063 99.96 Very High Very High Very High
Diabetes Mellitus 636 99.40 Very High Very High Very High
Dyslipidemia /

Combined Dyslipidemia

6 99.12 Very High Very High Very High
INFLAMMATION 256 98.48 Very High Very High Very High
Hypertension 27 97.68 Very High Very High Very High
Hyperinsulinism 127 97.24 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This study examines the effects of a relatively selective alpha 2-adrenoceptor antagonist, 8-(L-piperazinyl)imado-[1,2-alpha] pyrazine (compound A), and the preferential alpha 2-agonist clonidine on blood glucose, glucose tolerance, and plasma insulin levels in the C57BL/6J ob/ob mouse and its lean littermate.
Spec (examines) Regulation (effects) of in blood Gene_expression (levels) of insulin in plasma associated with antagonist, obesity, tolerance, agonist, impaired glucose tolerance and clonidine
1) Confidence 0.52 Published 1990 Journal Metab. Clin. Exp. Section Abstract Doc Link 1970847 Disease Relevance 0.74 Pain Relevance 0.71
Second, the low affinity fractions regulated Insulin expression in isolated islets, whereas the ones binding to HA with high affinity did not (Fig. 3 D).
Regulation (regulated) of Gene_expression (expression) of Insulin
2) Confidence 0.50 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2606962 Disease Relevance 0 Pain Relevance 0.03
The effect of dietary stearate on insulin sensitivity
Regulation (effect) of Gene_expression (sensitivity) of insulin
3) Confidence 0.38 Published 2010 Journal Nutr Metab (Lond) Section Body Doc Link PMC2852377 Disease Relevance 0 Pain Relevance 0
S1, G and H) indicate that the absence of leptin affects circulating insulin levels primarily by regulating insulin expression and secretion in addition to the possibility of changes of cell survival.
Regulation (regulating) of Gene_expression (expression) of insulin
4) Confidence 0.37 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2606962 Disease Relevance 0.67 Pain Relevance 0
Expression of the Insulin genes and of Glucokinase, a central component of the glucose-sensing machinery of ?
Regulation (sensing) of Gene_expression (Expression) of Insulin
5) Confidence 0.37 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2606962 Disease Relevance 0.91 Pain Relevance 0
Expression of Insulin, Glucokinase, and Cdk4 was up-regulated to the same extent in islets of adipocyte-deficient and ob/ob mice (Fig. 1 H), and insulin content was significantly increased in islets of adipocyte-deficient mice (Fig.
Regulation (regulated) of Gene_expression (Expression) of Insulin in adipocyte associated with obesity
6) Confidence 0.37 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2606962 Disease Relevance 0.73 Pain Relevance 0
Intracerebroventricular (i.c.v.) pretreatment with insulin dose- and time-dependently attenuated the antinociceptive effect of i.c.v.
Regulation (time-dependently) of Gene_expression (dose-) of insulin associated with antinociceptive and intracerebroventricular
7) Confidence 0.34 Published 1999 Journal Eur. J. Pharmacol. Section Abstract Doc Link 10414437 Disease Relevance 0 Pain Relevance 0.54
However, though acupuncture has the potential to improve pathological changes in the mitochondria [16], the biochemical mechanism underlying its effect on insulin resistance remains elusive.
Regulation (effect) of Gene_expression (resistance) of insulin associated with acupuncture and insulin resistance
8) Confidence 0.29 Published 2011 Journal Evidence-based Complementary and Alternative Medicine : eCAM Section Body Doc Link PMC2964507 Disease Relevance 0.58 Pain Relevance 0.32
However, unlike the studies from Iwakura et al. plasma insulin levels did not change after IP-GTT in those animals with high levels of UAG (L73).
Neg (not) Regulation (change) of Gene_expression (levels) of insulin in plasma
9) Confidence 0.28 Published 2010 Journal International Journal of Peptides Section Body Doc Link PMC2911604 Disease Relevance 0.58 Pain Relevance 0.09
Nevertheless UAG counteracts the effects of AG on glucose and insulin levels, but not its stimulatory action on GH, PRL, ACTH, and cortisol levels, indicating that UAG has metabolic impact, being able to antagonize the effects of AG on insulin and glucose levels, while it is really inactive from the neuroendocrine point of view [67].
Regulation (effects) of Gene_expression (levels) of insulin
10) Confidence 0.28 Published 2010 Journal International Journal of Peptides Section Body Doc Link PMC2911604 Disease Relevance 0.13 Pain Relevance 0.03
In the prediabetic phase, when insulin resistance has already begun, the ?
Regulation (begun) of Gene_expression (resistance) of insulin associated with insulin resistance
11) Confidence 0.28 Published 2010 Journal International Journal of Peptides Section Body Doc Link PMC2911604 Disease Relevance 1.82 Pain Relevance 0
To determine the role of insulin action in macrophages and monocytes in obesity-associated insulin resistance, we conditionally inactivated the insulin receptor (IR) gene in myeloid lineage cells in mice (IR?
Spec (determine) Regulation (role) of Gene_expression (action) of insulin in monocytes associated with obesity and insulin resistance
12) Confidence 0.27 Published 2010 Journal PLoS Genetics Section Abstract Doc Link PMC2865520 Disease Relevance 1.20 Pain Relevance 0.18
Myeloid cell-restricted insulin resistance does not affect obesity development upon high fat feeding
Neg (not) Regulation (affect) of in fat Gene_expression (resistance) of insulin in Myeloid cell associated with obesity and insulin resistance
13) Confidence 0.27 Published 2010 Journal PLoS Genetics Section Body Doc Link PMC2865520 Disease Relevance 1.41 Pain Relevance 0.08
Taken together, these results indicate that insulin receptors on myeloid cells are not required for energy homeostasis under NCD and HFD feeding and that myeloid cell-restricted insulin resistance does not affect the development of obesity upon high fat feeding.


Neg (not) Regulation (affect) of Gene_expression (resistance) of insulin in myeloid cell associated with obesity and insulin resistance
14) Confidence 0.27 Published 2010 Journal PLoS Genetics Section Body Doc Link PMC2865520 Disease Relevance 0.52 Pain Relevance 0
It appears that the changes in serum insulin level produced by various treatments may have a relationship with the antinociceptive response.
Regulation (changes) of Gene_expression (produced) of insulin associated with antinociceptive
15) Confidence 0.26 Published 2001 Journal Indian J. Exp. Biol. Section Abstract Doc Link 11883508 Disease Relevance 0.35 Pain Relevance 0.38
[Effect of clonidine on plasma insulin level in mice (author's transl)].
Regulation ([Effect) of Gene_expression (level) of insulin in plasma associated with clonidine
16) Confidence 0.25 Published 1978 Journal Nippon Yakurigaku Zasshi Section Title Doc Link 669483 Disease Relevance 0 Pain Relevance 0.31
To address the role of myeloid cell insulin action on whole body glucose metabolism, we next determined blood glucose and serum insulin concentrations in control- and IR?
Regulation (role) of Gene_expression (action) of insulin in blood
17) Confidence 0.23 Published 2010 Journal PLoS Genetics Section Body Doc Link PMC2865520 Disease Relevance 0.57 Pain Relevance 0.03
Baseline insulin levels did not differ between the groups, while the insulin response, as the glucagon response, was impaired after protein challenge (P = .018).
Neg (not) Regulation (differ) of Gene_expression (levels) of insulin
18) Confidence 0.17 Published 2008 Journal Experimental Diabetes Research Section Abstract Doc Link PMC2443691 Disease Relevance 0.43 Pain Relevance 0.15
The regulation of insulin production by glucose-responsive promoters in non-beta cells exhibits slow kinetics, which may cause hypoglycemia.
Regulation (regulation) of Gene_expression (production) of insulin in beta cells associated with hypoglycemia
19) Confidence 0.14 Published 2010 Journal Korean Diabetes Journal Section Body Doc Link PMC2883354 Disease Relevance 0.35 Pain Relevance 0
Thus, it is very difficult to mimic this tight regulation of insulin production in response to physiological levels of glucose in non-beta cells.


Regulation (regulation) of Gene_expression (production) of insulin in beta cells
20) Confidence 0.14 Published 2010 Journal Korean Diabetes Journal Section Body Doc Link PMC2883354 Disease Relevance 0.22 Pain Relevance 0

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