INT32152

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Context Info
Confidence 0.67
First Reported 1986
Last Reported 1986
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 3
Disease Relevance 0
Pain Relevance 1.53

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

small molecule metabolic process (POMC) cell-cell signaling (POMC) cytoplasm (POMC)
extracellular space (POMC) generation of precursor metabolites and energy (POMC) signal transduction (POMC)
Anatomy Link Frequency
mononuclear cells 4
natural killer cells 2
POMC (Homo sapiens)
IFNA1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Enkephalin 12 100.00 Very High Very High Very High
Opioid 12 93.88 High High
Neuropeptide 2 84.72 Quite High
opiate 3 63.92 Quite High
antagonist 3 63.64 Quite High
narcan 8 63.20 Quite High
opioid receptor 3 43.28 Quite Low

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Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Both beta-endorphin and Met-enkephalin enhanced IFN production by the majority of donor mononuclear cells tested and did so at concentrations between 10(-14) and 10(-10) M.
beta-endorphin Positive_regulation (enhanced) of Gene_expression (production) of IFN in mononuclear cells associated with enkephalin
1) Confidence 0.67 Published 1986 Journal Cell. Immunol. Section Abstract Doc Link 3026654 Disease Relevance 0 Pain Relevance 0.70
Both beta-endorphin and Met-enkephalin enhanced IFN production by the majority of donor mononuclear cells tested and did so at concentrations between 10(-14) and 10(-10) M.
Met-enkephalin Positive_regulation (enhanced) of Gene_expression (production) of IFN in mononuclear cells associated with enkephalin
2) Confidence 0.67 Published 1986 Journal Cell. Immunol. Section Abstract Doc Link 3026654 Disease Relevance 0 Pain Relevance 0.70
beta-Endorphin augments the cytolytic activity and interferon production of natural killer cells.
beta-Endorphin Positive_regulation (augments) of Gene_expression (production) of interferon in natural killer cells
3) Confidence 0.32 Published 1986 Journal J. Immunol. Section Title Doc Link 2934481 Disease Relevance 0 Pain Relevance 0.13

General Comments

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