INT321528

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Context Info
Confidence 0.41
First Reported 2010
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 1
Total Number 4
Disease Relevance 0.21
Pain Relevance 0.04

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Abcb1b) mitochondrion (Abcb1b) ATPase activity (Abcb1b)
transmembrane transport (Abcb1b)
Abcb1b (Mus musculus)
Pain Link Frequency Relevance Heat
tolerance 4 77.76 Quite High
anesthesia 4 5.00 Very Low Very Low Very Low
imagery 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Malaria 32 76.00 Quite High
Recurrence 4 32.00 Quite Low
Sprains And Strains 8 5.00 Very Low Very Low Very Low
Cancer 8 5.00 Very Low Very Low Very Low
Dislocations 4 5.00 Very Low Very Low Very Low
Falciparum Malaria 4 5.00 Very Low Very Low Very Low
Disease 4 5.00 Very Low Very Low Very Low
Vomiting 4 5.00 Very Low Very Low Very Low
Infection 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In order to determine whether the increase in genomic copies and transcription of the mdr1 gene was accompanied by an increase in its product, we measured the relative amount of MDR1 protein in the different parasite clones, using quantitative Western blot analysis.
Spec (whether) Positive_regulation (increase) of Transcription (transcription) of mdr1
1) Confidence 0.41 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2904698 Disease Relevance 0 Pain Relevance 0
Thus, the fold-increase of AS-ATNMF1 mdr1 mRNA transcripts was 2.6±0.17 and 3.4±0.22, relative to its single copy number progenitor AS-ATN and to AS-3CQ, respectively.
Positive_regulation (increase) of Transcription (transcripts) of mdr1
2) Confidence 0.38 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2904698 Disease Relevance 0 Pain Relevance 0
In this context, we investigated by real time PCR whether the evolution of ATN + MF-resistance had selected parasites with increased mdr1 copy number or mRNA expression.
Positive_regulation (increased) of Transcription (expression) of mdr1
3) Confidence 0.38 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2904698 Disease Relevance 0 Pain Relevance 0.04
Investigation of candidate genes revealed an mdr1 duplication in the resistant parasites and increased levels of mdr1 transcripts and protein.
Positive_regulation (increased) of Transcription (transcripts) of mdr1
4) Confidence 0.38 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2904698 Disease Relevance 0.21 Pain Relevance 0

General Comments

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