INT32153

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.49
First Reported 1984
Last Reported 2010
Negated 2
Speculated 0
Reported most in Body
Documents 14
Total Number 16
Disease Relevance 10.81
Pain Relevance 2.61

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (TNFRSF10B)
Anatomy Link Frequency
chondrocyte 2
TMJ 2
LGL 2
TNFRSF10B (Homo sapiens)
Pain Link Frequency Relevance Heat
Enkephalin 8 99.32 Very High Very High Very High
agonist 168 98.40 Very High Very High Very High
opioid receptor 1 97.64 Very High Very High Very High
COX-2 inhibitor 35 97.54 Very High Very High Very High
narcan 2 95.80 Very High Very High Very High
antagonist 139 93.56 High High
cINOD 27 90.80 High High
cytokine 79 87.28 High High
opiate 1 83.52 Quite High
Snapping jaw 4 75.00 Quite High
Disease Link Frequency Relevance Heat
Death 199 100.00 Very High Very High Very High
Apoptosis 988 99.92 Very High Very High Very High
Lung Cancer 48 98.84 Very High Very High Very High
Leukemia 34 98.12 Very High Very High Very High
Renal Cancer 12 96.92 Very High Very High Very High
Reprotox - General 1 30 94.32 High High
Cancer 467 90.92 High High
Herpes Simplex Virus 238 89.12 High High
Infection 104 88.24 High High
INFLAMMATION 52 84.52 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These findings demonstrate that b-end enhances NK activity and IFN production of purified LGL, and suggests that b-end might bind to an opioid receptor on LGL that can be blocked by naloxone.
Positive_regulation (enhances) of Gene_expression (production) of NK in LGL associated with narcan and opioid receptor
1) Confidence 0.49 Published 1986 Journal J. Immunol. Section Abstract Doc Link 2934481 Disease Relevance 0 Pain Relevance 0.26
At effector:target cell ratios of 11:1 methionine-enkephalin significantly (P less than 0.05) enhanced NK activity at dilutions of 10(-6), 10(-8), 10(-10), and 10(-14) mg/ml, while leucine-enkephalin significantly (P less than 0.05) enhanced NK activity at dilutions of 10(-4), 10(-6), 10(-8), 10(-10), and 10(-14) mg/ml.
Positive_regulation (enhanced) of Gene_expression (activity) of NK associated with enkephalin
2) Confidence 0.49 Published 1984 Journal Clin. Immunol. Immunopathol. Section Abstract Doc Link 6713744 Disease Relevance 0 Pain Relevance 0.70
Specimens were processed for immunohistochemistry to evaluate TRAIL and its receptor DR5 expression.
Positive_regulation (processed) of Gene_expression (expression) of DR5
3) Confidence 0.43 Published 2010 Journal Oral Surg Oral Med Oral Pathol Oral Radiol Endod Section Body Doc Link 20123409 Disease Relevance 0.08 Pain Relevance 0
CONCLUSIONS: TRAIL and DR5 are overexpressed in displaced human TMJ disc, especially in the posterior disc attachment.
Positive_regulation (overexpressed) of Gene_expression (overexpressed) of DR5 in TMJ
4) Confidence 0.43 Published 2010 Journal Oral Surg Oral Med Oral Pathol Oral Radiol Endod Section Body Doc Link 20123409 Disease Relevance 0.05 Pain Relevance 0
increases DR5 expression at the mRNA level [49].
Positive_regulation (increases) of Gene_expression (expression) of DR5
5) Confidence 0.35 Published 2008 Journal PPAR Research Section Body Doc Link PMC2442903 Disease Relevance 1.06 Pain Relevance 0.07
overexpressed or DR5 was silenced, PPAR?
Positive_regulation (overexpressed) of Gene_expression (overexpressed) of DR5
6) Confidence 0.35 Published 2008 Journal PPAR Research Section Body Doc Link PMC2442903 Disease Relevance 0.75 Pain Relevance 0.23
to induce DR5 expression and augment TRAIL-induced apoptosis in Jurkat leukemia
Positive_regulation (induce) of Gene_expression (expression) of DR5 associated with leukemia and apoptosis
7) Confidence 0.35 Published 2008 Journal PPAR Research Section Body Doc Link PMC2442903 Disease Relevance 0.79 Pain Relevance 0.18
Overexpression of DR5 receptor and its ligand (TRAIL) in chondrocyte-like cells suggested activation of programmed cell death, as also demonstrated by TUNEL-positive cells.
Positive_regulation (Overexpression) of Gene_expression (Overexpression) of DR5 receptor in chondrocyte associated with apoptosis
8) Confidence 0.33 Published 2009 Journal Histol. Histopathol. Section Abstract Doc Link 19130398 Disease Relevance 0.66 Pain Relevance 0.15
Upregulation of DR5 expression was observed in HepG2 cells after treatment with delisheng.
Positive_regulation (Upregulation) of Gene_expression (expression) of DR5
9) Confidence 0.29 Published 2009 Journal Mol Biol Rep Section Abstract Doc Link PMC2941086 Disease Relevance 0.27 Pain Relevance 0
not upregulate DR5 expression and pretreatment with GW9662, a PPAR?
Neg (not) Positive_regulation (upregulate) of Gene_expression (expression) of DR5
10) Confidence 0.25 Published 2008 Journal PPAR Research Section Body Doc Link PMC2442903 Disease Relevance 0.89 Pain Relevance 0.12
and GW1929 induce the expression of death receptor 5 (DR5) including increasing
Positive_regulation (induce) of Gene_expression (expression) of death receptor associated with death
11) Confidence 0.23 Published 2008 Journal PPAR Research Section Body Doc Link PMC2442903 Disease Relevance 0.69 Pain Relevance 0.27
ligands can increase death receptor expression
Positive_regulation (increase) of Gene_expression (expression) of death receptor associated with death
12) Confidence 0.23 Published 2008 Journal PPAR Research Section Body Doc Link PMC2442903 Disease Relevance 1.71 Pain Relevance 0.03
We found that DLS treatment upregulated the expression of death receptor DR5.
Positive_regulation (upregulated) of Gene_expression (expression) of death receptor DR5 associated with death
13) Confidence 0.18 Published 2009 Journal Mol Biol Rep Section Body Doc Link PMC2941086 Disease Relevance 1.30 Pain Relevance 0.04
Moreover, increases in expression levels of death receptor DR5 (Fig. 3b) confirmed the activation of the extrinsic apoptosis pathway.
Positive_regulation (increases) of Gene_expression (expression) of death receptor DR5 associated with apoptosis and death
14) Confidence 0.17 Published 2009 Journal Mol Biol Rep Section Body Doc Link PMC2941086 Disease Relevance 0.98 Pain Relevance 0
Though the selective COX-2 inhibitors cause only occasional deleterious effects, they have also been shown to exhibit some COX-2 independent effects such as up-regulation of death receptor 5 (DR5) expression, inhibition of survival signal pathways, and augmentation of apoptosis [43],[44].
Positive_regulation (regulation) of Gene_expression (expression) of death receptor 5 associated with cox-2 inhibitor, apoptosis and death
15) Confidence 0.15 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2820536 Disease Relevance 0.83 Pain Relevance 0.22
Whereas treatment with R-flurbiprofen or ibuprofen resulted in a massive induction of p75(NTR) protein levels, the expression of Fas, p55(TNFR), DR3, DR4, DR5, and DR6 remained largely unchanged.
Neg (unchanged) Positive_regulation (unchanged) of Gene_expression (expression) of DR5
16) Confidence 0.04 Published 2007 Journal Cancer Res. Section Abstract Doc Link 17409433 Disease Relevance 0.76 Pain Relevance 0.34

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox