INT32155

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Context Info
Confidence 0.67
First Reported 1984
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 36
Total Number 44
Disease Relevance 30.32
Pain Relevance 5.74

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (TNFRSF10B)
Anatomy Link Frequency
Macrophages 1
chondrocyte 1
plasma 1
colon 1
TMJ 1
TNFRSF10B (Homo sapiens)
Pain Link Frequency Relevance Heat
Enkephalin 8 99.14 Very High Very High Very High
qutenza 56 98.80 Very High Very High Very High
agonist 435 97.96 Very High Very High Very High
opioid receptor 1 97.64 Very High Very High Very High
COX-2 inhibitor 128 97.26 Very High Very High Very High
antagonist 363 95.84 Very High Very High Very High
narcan 2 95.80 Very High Very High Very High
tetrodotoxin 1 94.44 High High
cytokine 181 93.24 High High
cINOD 79 90.24 High High
Disease Link Frequency Relevance Heat
Death 546 100.00 Very High Very High Very High
Apoptosis 2743 99.90 Very High Very High Very High
Colon Cancer 239 99.38 Very High Very High Very High
Glioma 36 99.22 Very High Very High Very High
Lung Cancer 191 98.84 Very High Very High Very High
Rheumatoid Arthritis 40 98.60 Very High Very High Very High
Leukemia 95 98.12 Very High Very High Very High
Renal Cancer 30 96.52 Very High Very High Very High
Cancer 1501 94.52 High High
Reprotox - General 1 76 94.32 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
CONCLUSIONS: TRAIL and DR5 are overexpressed in displaced human TMJ disc, especially in the posterior disc attachment.
Gene_expression (overexpressed) of DR5 in TMJ
1) Confidence 0.67 Published 2010 Journal Oral Surg Oral Med Oral Pathol Oral Radiol Endod Section Body Doc Link 20123409 Disease Relevance 0.05 Pain Relevance 0
Specimens were processed for immunohistochemistry to evaluate TRAIL and its receptor DR5 expression.
Gene_expression (expression) of DR5
2) Confidence 0.67 Published 2010 Journal Oral Surg Oral Med Oral Pathol Oral Radiol Endod Section Body Doc Link 20123409 Disease Relevance 0.07 Pain Relevance 0
Progesterone may rapidly change membrane potential, and eventually function, by acting on putative NK plasma membrane receptors coupled to Na+ conductances.
Gene_expression (acting) of NK in plasma
3) Confidence 0.65 Published 1993 Journal Nat. Immun. Section Abstract Doc Link 8392407 Disease Relevance 0 Pain Relevance 0.18
At effector:target cell ratios of 11:1 methionine-enkephalin significantly (P less than 0.05) enhanced NK activity at dilutions of 10(-6), 10(-8), 10(-10), and 10(-14) mg/ml, while leucine-enkephalin significantly (P less than 0.05) enhanced NK activity at dilutions of 10(-4), 10(-6), 10(-8), 10(-10), and 10(-14) mg/ml.
Gene_expression (activity) of NK associated with enkephalin
4) Confidence 0.65 Published 1984 Journal Clin. Immunol. Immunopathol. Section Abstract Doc Link 6713744 Disease Relevance 0 Pain Relevance 0.70
These findings demonstrate that b-end enhances NK activity and IFN production of purified LGL, and suggests that b-end might bind to an opioid receptor on LGL that can be blocked by naloxone.
Gene_expression (production) of NK in LGL associated with narcan and opioid receptor
5) Confidence 0.65 Published 1986 Journal J. Immunol. Section Abstract Doc Link 2934481 Disease Relevance 0 Pain Relevance 0.26
This is the first study that shows that intervertebral disk cells express TRAIL, DR4 and DR5, which correlate to the degenerative state of the disk.
Gene_expression (express) of DR5
6) Confidence 0.64 Published 2009 Journal Mod. Pathol. Section Abstract Doc Link 19305384 Disease Relevance 0.35 Pain Relevance 0.04
Isolated disk cells were analyzed by flow cytometry for Fas, FasL, TRAIL, DR4 and DR5 expression.
Spec (analyzed) Gene_expression (expression) of DR5
7) Confidence 0.64 Published 2009 Journal Mod. Pathol. Section Abstract Doc Link 19305384 Disease Relevance 0.74 Pain Relevance 0.10
There was a significantly higher percentage of stained cells in the posterior disc attachment compared with the anterior or intermediate bands of both ADDwR and ADDwoR discs for TRAIL and DR5.
Gene_expression (bands) of DR5 in bands
8) Confidence 0.58 Published 2010 Journal Oral Surg Oral Med Oral Pathol Oral Radiol Endod Section Body Doc Link 20123409 Disease Relevance 0.06 Pain Relevance 0
Expression of TRAIL and the death receptors DR4 and DR5 correlates with progression of degeneration in human intervertebral disks.
Gene_expression (Expression) of DR5 associated with death
9) Confidence 0.56 Published 2009 Journal Mod. Pathol. Section Title Doc Link 19305384 Disease Relevance 0.79 Pain Relevance 0.13
Overexpression of DR5 receptor and its ligand (TRAIL) in chondrocyte-like cells suggested activation of programmed cell death, as also demonstrated by TUNEL-positive cells.
Gene_expression (Overexpression) of DR5 receptor in chondrocyte associated with apoptosis
10) Confidence 0.43 Published 2009 Journal Histol. Histopathol. Section Abstract Doc Link 19130398 Disease Relevance 0.66 Pain Relevance 0.15
increases DR5 expression at the mRNA level [49].
Gene_expression (expression) of DR5
11) Confidence 0.39 Published 2008 Journal PPAR Research Section Body Doc Link PMC2442903 Disease Relevance 1.01 Pain Relevance 0.07
to induce DR5 expression and augment TRAIL-induced apoptosis in Jurkat leukemia
Gene_expression (expression) of DR5 associated with leukemia and apoptosis
12) Confidence 0.39 Published 2008 Journal PPAR Research Section Body Doc Link PMC2442903 Disease Relevance 0.79 Pain Relevance 0.18
and GW1929 induce the expression of death receptor 5 (DR5) including increasing
Gene_expression (expression) of death receptor associated with death
13) Confidence 0.39 Published 2008 Journal PPAR Research Section Body Doc Link PMC2442903 Disease Relevance 0.69 Pain Relevance 0.27
not upregulate DR5 expression and pretreatment with GW9662, a PPAR?
Gene_expression (expression) of DR5
14) Confidence 0.39 Published 2008 Journal PPAR Research Section Body Doc Link PMC2442903 Disease Relevance 0.88 Pain Relevance 0.12
overexpressed or DR5 was silenced, PPAR?
Gene_expression (overexpressed) of DR5
15) Confidence 0.39 Published 2008 Journal PPAR Research Section Body Doc Link PMC2442903 Disease Relevance 0.75 Pain Relevance 0.23
(R140M7) motifs of the DR5 was sufficient to strongly reduce RA-dependent transactivation but did not block stimulation by DREAM.
Gene_expression (motifs) of DR5 associated with rheumatoid arthritis
16) Confidence 0.35 Published 2005 Journal Nucleic Acids Research Section Body Doc Link PMC1084319 Disease Relevance 0.31 Pain Relevance 0
Thus, on DR3 and DR5, RXR occupies the 5?
Gene_expression (occupies) of DR5
17) Confidence 0.35 Published 2005 Journal Nucleic Acids Research Section Body Doc Link PMC1084319 Disease Relevance 0 Pain Relevance 0
The use of a DR5/Fc chimeric
Gene_expression (chimeric) of DR5
18) Confidence 0.34 Published 2008 Journal PPAR Research Section Body Doc Link PMC2442903 Disease Relevance 1.08 Pain Relevance 0.07
the cell surface distribution of DR5, reducing the levels of c-FLIP, and
Gene_expression (reducing) of DR5
19) Confidence 0.34 Published 2008 Journal PPAR Research Section Body Doc Link PMC2442903 Disease Relevance 0.69 Pain Relevance 0.26
overexpressed or DR5 was silenced, PPAR?
Gene_expression (overexpressed) of DR5
20) Confidence 0.34 Published 2008 Journal PPAR Research Section Body Doc Link PMC2442903 Disease Relevance 0.75 Pain Relevance 0.23

General Comments

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