INT321566

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Context Info
Confidence 0.23
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 1.07
Pain Relevance 0.06

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Ctsb) mitochondrion (Ctsb) extracellular space (Ctsb)
extracellular region (Ctsb) lysosome (Ctsb) cytoplasm (Ctsb)
Ctsb (Mus musculus)
Pain Link Frequency Relevance Heat
metalloproteinase 4 65.12 Quite High
Central nervous system 1 13.64 Low Low
potassium channel 1 5.00 Very Low Very Low Very Low
Inward rectifier potassium channel 1 5.00 Very Low Very Low Very Low
cINOD 1 5.00 Very Low Very Low Very Low
anesthesia 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Glioblastoma 11 98.80 Very High Very High Very High
Glioma 59 89.12 High High
Anaplastic Astrocytoma 2 79.96 Quite High
Brain Tumor 1 76.76 Quite High
Cancer 73 67.52 Quite High
Malignant Neoplastic Disease 5 59.88 Quite High
Adhesions 30 50.24 Quite High
Central Nervous System Cancer 1 13.64 Low Low
Disease Progression 1 8.72 Low Low
Apoptosis 11 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Additionally, uPA-uPAR binding results in the expression of cathepsin B [21], another important protease involved in ECM degradation, and significantly higher levels of cathepsin B has been found in high-grade glioblastomas [22], [23].
Protein_catabolism (degradation) of cathepsin B associated with glioblastoma
1) Confidence 0.23 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2904700 Disease Relevance 0.88 Pain Relevance 0.06
Our study indicates that cathepsin B and uPAR knockdown induces G0/G1 arrest by modulating the PI3K/AKT signaling pathway and further increases expression of p27Kip1 accompanied by the binding of FOXO3a to its promoter.
Protein_catabolism (knockdown) of cathepsin B
2) Confidence 0.08 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2908539 Disease Relevance 0.19 Pain Relevance 0

General Comments

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