INT3216

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Context Info
Confidence 0.69
First Reported 1978
Last Reported 2011
Negated 10
Speculated 4
Reported most in Abstract
Documents 170
Total Number 176
Disease Relevance 56.78
Pain Relevance 35.63

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Ins1) extracellular region (Ins1) carbohydrate metabolic process (Ins1)
cytoplasm (Ins1)
Anatomy Link Frequency
plasma 17
pancreatic islets 14
alpha cell 8
blood 8
sensory nerves 8
Ins1 (Mus musculus)
Pain Link Frequency Relevance Heat
agonist 728 99.98 Very High Very High Very High
tolerance 715 99.96 Very High Very High Very High
Clonidine 100 99.84 Very High Very High Very High
Enkephalin 66 99.80 Very High Very High Very High
opiate 39 99.80 Very High Very High Very High
lidocaine 20 99.80 Very High Very High Very High
narcan 57 99.72 Very High Very High Very High
qutenza 49 99.70 Very High Very High Very High
Dynorphin 55 99.68 Very High Very High Very High
anesthesia 41 99.56 Very High Very High Very High
Disease Link Frequency Relevance Heat
Impaired Glucose Tolerance 715 100.00 Very High Very High Very High
Hyperinsulinism 339 100.00 Very High Very High Very High
Diabetes Mellitus 3560 99.96 Very High Very High Very High
Hypoglycemia 643 99.92 Very High Very High Very High
Hyperglycemia 448 99.92 Very High Very High Very High
Targeted Disruption 1629 99.70 Very High Very High Very High
Congenital Anomalies 130 99.62 Very High Very High Very High
Insulin Resistance 971 99.60 Very High Very High Very High
Systemic Lupus Erythematosus 8 99.48 Very High Very High Very High
Appetite Loss 105 99.40 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Both enantiomers were equipotent in potentiating insulin release induced by 15 mM glucose alone.
Positive_regulation (induced) of Localization (release) of insulin
1) Confidence 0.69 Published 1994 Journal Eur. J. Pharmacol. Section Abstract Doc Link 7828647 Disease Relevance 0 Pain Relevance 0.10
When alpha 2-adrenoceptors were blocked by the antagonist idazoxan, the low concentrations of SL 84.0418 (0.1-0.3 microM) no longer increased insulin release, whereas the effect of higher concentrations (> or = 1 microM) was not affected.
Positive_regulation (increased) of Localization (release) of insulin associated with antagonist and hyperinsulinism
2) Confidence 0.69 Published 1994 Journal Eur. J. Pharmacol. Section Abstract Doc Link 7911430 Disease Relevance 0.10 Pain Relevance 0.42
It was recently reported to inhibit alpha 2-adrenoceptors and ATP-sensitive K+ channels in mouse pancreatic B-cells, and to increase insulin release.
Positive_regulation (increase) of Localization (release) of insulin in B-cells
3) Confidence 0.69 Published 1994 Journal Eur. J. Pharmacol. Section Abstract Doc Link 7828647 Disease Relevance 0 Pain Relevance 0.04
The observed differences in glucose metabolism between normal and transplanted mice may be attributed to the site of transplantation and to the use of rat islets, which have a different set point for glucose induced insulin release.


Positive_regulation (induced) of Localization (release) of insulin
4) Confidence 0.69 Published 1999 Journal Transplantation Section Body Doc Link 10096520 Disease Relevance 0 Pain Relevance 0
In conclusion, the obtained results suggest that insulin secretion regulated by autonomic nervous homeostasis can be changed by pentobarbital through decrement in sympathetic tone to increase the insulin secretion induced by agent(s) via higher of parasympathetic tone.
Positive_regulation (increase) of Localization (secretion) of insulin in sympathetic
5) Confidence 0.68 Published 2010 Journal Neurosci. Lett. Section Abstract Doc Link 20471451 Disease Relevance 0.08 Pain Relevance 0.11
Blockade of muscarinic receptors by atropine inhibited ginseng-induced insulin secretion in anesthetized mice.
Positive_regulation (induced) of Localization (secretion) of insulin
6) Confidence 0.68 Published 2010 Journal Neurosci. Lett. Section Abstract Doc Link 20471451 Disease Relevance 0.09 Pain Relevance 0.12
Further support for the idea that isosmolar addition of rapidly penetrating molecules induces insulin release was obtained by testing non-metabolizable glucose analogues.
Positive_regulation (induces) of Localization (release) of insulin
7) Confidence 0.68 Published 1992 Journal Mol. Cell. Biochem. Section Abstract Doc Link 1614421 Disease Relevance 0.07 Pain Relevance 0.14
Lidocaine, 1-5 mM, stimulated basal insulin release, but 1 microM-1 mM of the drug did not affect glucose-induced (20 mM glucose) insulin release and 5 mM lidocaine inhibited glucose stimulation.
Positive_regulation (stimulated) of Localization (release) of insulin associated with lidocaine
8) Confidence 0.67 Published 1983 Journal Biochim. Biophys. Acta Section Abstract Doc Link 6351931 Disease Relevance 0 Pain Relevance 0.57
Insulin release induced by 20 mM glucose was potentiated by 0.1 mM and 0.5 mM tetracaine, but this effect disappeared at 1 mM tetracaine.
Positive_regulation (induced) of Localization (release) of Insulin
9) Confidence 0.67 Published 1983 Journal Biochim. Biophys. Acta Section Abstract Doc Link 6351931 Disease Relevance 0 Pain Relevance 0.31
The results indicate that tetracaine and lidocaine, at certain concentrations, can induce insulin release and that tetracaine potentiates secretion induced by other secretagogues.
Positive_regulation (induce) of Localization (release) of insulin associated with lidocaine
10) Confidence 0.67 Published 1983 Journal Biochim. Biophys. Acta Section Abstract Doc Link 6351931 Disease Relevance 0 Pain Relevance 0.49
Regardless of the stimulus used to induce insulin release, the inhibitory effect of low concentrations of clonidine (0.01-0.1 microM) was markedly smaller in the absence of Na+ (with choline or lithium as substitute) than in its presence.
Positive_regulation (induce) of Localization (release) of insulin associated with clonidine
11) Confidence 0.67 Published 1990 Journal Life Sci. Section Abstract Doc Link 1975083 Disease Relevance 0 Pain Relevance 0.25
Both AIB and L-alanine promptly induced transient insulin release during column perifusion of islet cells.
Positive_regulation (induced) of Localization (release) of insulin
12) Confidence 0.65 Published 1997 Journal Pancreas Section Abstract Doc Link 8981509 Disease Relevance 0.10 Pain Relevance 0.08
It is concluded that amino acids can stimulate insulin release from mature beta cells by virtue of being cotransported with Na+.
Positive_regulation (stimulate) of Localization (release) of insulin in beta cells
13) Confidence 0.65 Published 1997 Journal Pancreas Section Abstract Doc Link 8981509 Disease Relevance 0.07 Pain Relevance 0.08
The impact of sensory nerves in glucose-stimulated insulin secretion and glucose tolerance was investigated in conscious mice treated neonatally with either capsaicin (Cap) or vehicle (Veh).
Positive_regulation (stimulated) of Localization (secretion) of insulin in sensory nerves associated with qutenza, tolerance and impaired glucose tolerance
14) Confidence 0.64 Published 1994 Journal Am. J. Physiol. Section Abstract Doc Link 7943418 Disease Relevance 0.17 Pain Relevance 0.63
Glucose-stimulated insulin release from pancreatic islets of ob/ob-mice was inhibited by 10(-9) M of the alpha 2-adrenergic agonist clonidine.
Positive_regulation (stimulated) of Localization (release) of insulin in pancreatic islets associated with agonist and clonidine
15) Confidence 0.63 Published 1983 Journal Res. Commun. Chem. Pathol. Pharmacol. Section Abstract Doc Link 6364277 Disease Relevance 0 Pain Relevance 0.41
The newly introduced alpha 2-adrenoceptor antagonist BDF 8933, which is an imidazoline derivative, stimulates insulin release as well, while the irreversible alpha-adrenoceptor blocking agent benextramine of different structure failed to do so, even when being present in concentrations blocking the alpha 2-adrenoceptor-mediated effects of clonidine.
Positive_regulation (stimulates) of Localization (release) of insulin associated with antagonist and clonidine
16) Confidence 0.61 Published 1989 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 2572976 Disease Relevance 0 Pain Relevance 0.30
As we have demonstrated previously phentolamine stimulates the release of additional insulin from isolated mouse islets and raises plasma insulin levels in the whole rat.
Positive_regulation (stimulates) of Localization (release) of insulin in plasma
17) Confidence 0.61 Published 1989 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 2572976 Disease Relevance 0 Pain Relevance 0
When used under our conditions, it almost entirely failed to alleviate the inhibition of insulin release induced by clonidine.
Positive_regulation (induced) of Localization (release) of insulin associated with clonidine
18) Confidence 0.61 Published 1989 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 2572976 Disease Relevance 0 Pain Relevance 0.30
In experiments on isolated pancreatic islets from mice we now demonstrate that tolazoline and antazoline which are chemically closely related to phentolamine, share its ability to potentiate insulin release.
Positive_regulation (potentiate) of Localization (release) of insulin in pancreatic islets
19) Confidence 0.61 Published 1989 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 2572976 Disease Relevance 0 Pain Relevance 0.11
Antazoline shared the ability of phentolamine to stimulate insulin release despite having no or only very little alpha-adrenoceptor blocking activity.
Positive_regulation (stimulate) of Localization (release) of insulin
20) Confidence 0.61 Published 1989 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 2572976 Disease Relevance 0 Pain Relevance 0.31

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